Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies

Study of the Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03811964

Enrollment

726

Registered

2019-01-22

Start date

2020-01-22

Completion date

2028-02-01

Last updated

2026-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurological Pathologies, Ophthalmological Pathologies, Psychiatric Pathologies, Sleep Disorders

Brief summary

The light has visual and non-visual effects on organism and can act on the behavior, the mood, the cognition and the sleep. These effects are mediated by "classical" retina photoreceptors which allow vision (rods, cones) but also melanopsin cells. The non-visual effects of light seems to be altered in many neurological, psychiatric or ophtalmological conditions but their exact role in the pathogenesis remains poorly understand. The purpose of the study is to increase our knowledge of the non-visual effects of light and establish new therapeutic applications

Interventions

OTHERSpecific light exposures

Specific light exposures using light in a wide range of intensities or different light/dark regimens

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Man or woman * Aged 18 years or older * Subject having signed a free and informed consent * Subject affiliated to a social protection scheme Arm 1 :Subjects with primary sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric pathology pathology with disorder of the controls of the wake and the sleep Arm 4 : subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with regulation disorder of sleep and wake Arm 6 : healthy subject

Exclusion criteria

Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa, macular involvement of diabetes) * Cataract with significant vision loss \<5/10 * Chorioretinal neovascularization * Subject in exclusion period determined by previous or current study * Impossibility to give the subject information enlightened (subject in emergency situation, difficulties of understanding the subject, ...) * Subject under the protection of justice * Subject under guardianship or curatorship * Pregnancy / Breastfeeding

Design outcomes

Primary

Measure	Time frame	Description
PIPR : Post-Illumination Pupil Response	1 day	1 measurement per subject is performed after exposure to monochromatic light exposure

Countries

France

Contacts

CONTACTBourgin Patrice, MD

pbourgin@unistra.fr03 88 11 64 30

PRINCIPAL_INVESTIGATORBourgin Patrice, MD

University Hospital, Strasbourg, France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 21, 2026