Sepsis
Conditions
Keywords
Fluid Therapy, Gender difference
Brief summary
In this single-center study the investigators will analyze gender differences among patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years. About 11 000 patients will be included. Patient data including fluid therapy will be drawn from the electronic medical record; Take Care and Clinisoft. In the logistic regression analysis, the investigators will adjust for age, gender, comorbidities, vital signs, preliminary focus of infection, level of care and renal replacement therapy. The aim is to analyze gender differences in fluid treatment and the response to fluid treatment and if the treatment is associated with differences in mortality.
Interventions
None listed
Sponsors
Karolinska Institutet
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to the emergency department with suspected sepsis (defined by blood culture taken and intravenous sepsis-antibiotics prescribed within 48 hours) and fulfilling sepsis-3 definition of sepsis (sequential organ failure assesment score of 2 or more)
Exclusion criteria
* Patients transferred from other hospitals or treatment clinics.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gender differences in fluid treatment | Fluid therapy during the first six hours (adherence to sepsis bundles) and the first five days after admission. | Millilitres of fluid given per kilogram of patient weight (ml/kg). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between amount of fluid and mortality | In-Hospital Mortality, 30- and 90-days mortality | Analyze the whole cohort and female/ male gender as subgroups |
| Type of fluids | First five days after admission. | Type according to Anatomical, Therapeutic and Chemical Classification System |
| Association between fluid therapy and levels of lactat | First five days efter admission | Analyze the whole cohort and female/ male gender as subgroups |
| Association between fluid therapy and need for/ dose of vasopressors/inotropic drugs | First five days efter admission | Analyze the whole cohort and female/ male gender as subgroups |
Countries
Sweden
Contacts
Primary ContactSandra Jonmarker
Backup ContactMaria Cronhjort, Ph D
Outcome results
None listed