Dementia
Conditions
Keywords
Dementia
Brief summary
This study aimed to clarify whether strength training or aerobic training could bring more benefits for patients with dementia, another study is to clarify whether isokinetic or isotonic training could bring more benefits for patients with mild cognitive impairment
Detailed description
Exercise training has been evidenced to bring various of benefits for patients with dementia in past studies. However, whether strength training or aerobic training could bring better benefits has not been confirmed in the past. This study designed to recruit 30 patients with mild dementia in the first year. Every patient will receive strength training using dumbbells, butterfly machine and vertical leg press machine for four weeks. Outcome measures including self care ability, cognitive function, MCP-1, BDNF and IGF-1 levels, and the degree of depression will be recorded before and after the training. In the second year, the investigators also designed to recruit 31 patients with mild dementia. These participants will instead receive aerobic training using stationary bicycle for four weeks. The same outcome measures will be tested as in the first year. The other part of the study recruited 46 patients with mild cognitive impairment, who were randomized into either a four-week isokinetic or isotonic training program. All cases were evaluated by isokinetic peak torque, 36-item Short Form Survey (SF-36), Mini-Mental State Examination (MMSE), Barthel Index, geriatric depression scale (GDS-15), and Timed Up and Go test (TUG test) before and after each kind of training.
Interventions
DEVICEStrength training
Using dumbbells, butterfly machine and vertical leg press machine for strength training, 12 repetition maximum weight for 12 repetition, three times a day, five days a week, for a total of four weeks
DEVICEAerobic training
Using stationary bicycle to perform cardiopulmonary endurance training in 50-70 heart rate reserve for 20 minutes, five days per week, for a total of four weeks
DEVICEIsokinetic trinaing
Using Biodex isokinetic dynanometer and set it in isokinetic mode in 60 degree per second
DEVICEIsotonic training
Using Biodex isokinetic dynanometer and set it in isotonic mode at 60% of the maximal peak torque
Sponsors
Taichung Veterans General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Intervention model description
comparison of therapeutic effect between aerobic and strength training on dementia patient, and comparison of therapeutic effect between isokinetic and isotonic training on patients with mild cognitive impairment
Eligibility
Sex/Gender
ALL
Age
40 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
1. Patients aged above 65 years old 2. Patients with mild dementia with Mini-mental state examination scoring 15 to 26 3. Another arm is patients with mild cognitive impairment and Mini-mental state examination scoring 23 to 27
Exclusion criteria
1. Cardiopulmonary diseases or orthopedical conditions that prohibit the patient from receiving exercise training of our programs 2. Cognitive problems that impede the patient to understand and answer the content of our questionnaires.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SF-36 | 4 weeks | consists of 36 questions categorized into 8 subdomains, including physical functioning, role limitations due to physical health, pain, general health condition, vitality, social functioning, role limitations due to emotional problems, and emotional well-being. |
| Montreal Cognitive Assessment | 4 weeks | To evaluate cognitive function, range from 0-30, higher values represent a better outcome |
| Geriatric Depression Scale | 4 weeks | To evaluate patient's depression status, range from 0-15, higher values represent a worse outcome |
| Timed up and go test | 4 weeks | Measure the time taken by a patient to stand up from a chair, walk three meters, return, and sit back on the chair |
| Barthel index | 4 weeks | To evaluate function of activities of daily living, range from 0-100, higher values represent a better outcome |
| Mini-mental state examination | 4 weeks | To evaluate cognitive function, range from 0-30, higher values represent a better outcome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of plasma insulin-like growth factor-1 (IGF-1) | 4 weeks | Lower plasma level of IGF-1 is associated with an increased risk of developing Alzheimer's dementia, and higher levels of it may protect against neurodegeneration. |
| Concentration of plasmamonocyte chemotactic protein-1 (MCP-1) | 4 weeks | The elevation of MCP-1 concentration usually means the progression of systemic inflammation. |
| Concentration of serum brain derived neurotrophic factor (BDNF) | 4 weeks | Increasing BDNF level is related to preventing neurodegeneration. |
Countries
Taiwan
Outcome results
None listed