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Postural Stability in Cervical Spinal Myelopathy

Study of Postural Stability in Subjects With Myelopathy Using a Portable Virtual Reality Balance Protocol

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03810781
Enrollment
8
Registered
2019-01-22
Start date
2019-02-07
Completion date
2022-09-01
Last updated
2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Spondylotic Myelopathy

Keywords

Posturography, Spinal Cord Injury

Brief summary

Veterans are at heightened risk of developing cervical spondylotic myelopathy (CSM) from rigors of military service. Balance and posturography are negatively affected in CSM, but require expensive equipment, and extensive training of personnel for data acquisition and interpretation. The Virtual Environment TBI Screen (VETS) is a simple and inexpensive construct that could be implemented as an aid in diagnosis and as an objective means to compare treatment modalities and track recovery. The goal for the SPiRE is to generate the critical data to support rigorous Merit studies of posturography for assessments of clinical course in the treatment and rehabilitation of CSM. The investigators' ultimate goal, if the SPiRE is successful, is to phase in objective posturography assessments as VA standard of care in CSM.

Detailed description

COVID-19 administrative hold Veterans are at heightened risk of developing cervical spondylotic myelopathy (CSM) from rigors of military service. Diagnosis of CSM involves a set of clinical findings and is confirmed by imaging the spine. Gait impairment and disturbances of stance control are hallmarks of CSM and are a consequence of abnormalities in proprioception due to dorsal column tract damage of the spine. Currently, gait and balance deficits rely on clinical level assessments and judgement for detection. An objective measure of posturography has the benefit of: a) quantifying balance-related disability in CSM, b) facilitating structure-functional assessments in CSM, and c) quantifying the degree surgical interventions affect posturography and recovery of function in CSM. Objective and sensitive means for assessing balance and posturography exist, but are not routinely incorporated in diagnosis or functional tracking of progress after interventions such as surgery. A barrier may be accessibility of posturography and ease of assessments. The Virtual Environment TBI Screen (VETS) was devised using Army Rapid Innovation Development funding to objectively assess balance and posturography in a cost effective, but sensitive manner. VETS involves virtual environments and computerized posturography and is proving to be a sensitive system facilitating diagnosis, treatment, and mitigation of balance dysfunction associated with mTBI. The working hypothesis is VETS testing will enhance clinical judgements regarding CSM. The SPiRE is designed to provide data critical to a more extensive program of research incorporating posturography into treatment and rehabilitation of CSM. First, a limited comparative study of standing balance will be conducted of 20 Veterans being evaluated for cervical spine surgery to treat CSM and 20 otherwise healthy Veterans. Second, posturography of the Veterans undergoing surgery to treat CSM will be tracked during their scheduled follow up visits to determine the degree VETS scores are affected by surgery and to track recovery from CSM. Patients in the CSM group will be selected based on clinical criteria. Veterans in the control group will be recruited from the Syracuse Veterans Affairs Medical Center (SVAMC) and surrounding community. For VETS testing, the Veteran will stand directly on a firm surface or foam pad placed on top of a Wii Balance Board (WBB). There are six conditions manipulating surface (firm or foam surface) and visual input (eyes open viewing a static scene, eyes closed, and eyes open viewing a dynamic visual scene). The primary measure is the center of pressure (COP) sway area. These 6 conditions allow for an assessment of generalized vs specific deficits in COP sway area considering proprioception, dependence of visual input and visuo-proprioceptive integration. AIM 1A: Determine whether and to what degree balance is altered in CSM. The degree of COP sway will be compared between CSM and controls in the six conditions comprising VETS testing. AIM 1B: Determine whether VETS enhances sensitivity and selectivity in the diagnosis of CSM. Composite measures of balance will be related to clinical assessment tools and their relationship with MRI. AIM 2: Evaluate the VETS scores after surgery to treat CSM. The degree of COP sway area under the 6 conditions will be compared before surgery, 2 weeks, 6 weeks and 6 months after surgery (corresponding with post-operative clinical assessments). The ultimate goal is to validate and incorporate objective balance testing into routine assessment for CSM to aid in disambiguating CSM, to improve functional assessments of recovery, and to aid in evaluations of different treatment and rehabilitation strategies in CSM for the Veteran population.

Interventions

None listed

Sponsors

Temple University
CollaboratorOTHER
VA Office of Research and Development
Lead SponsorFED

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

Patients in the CSM group will be selected based on clinical criteria. Inclusion criteria for the CSM group are: * symptoms of myelopathy in upper and lower extremities and stenosis of the cervical spine demonstrated by MRI or myelography * lower extremity muscle strength of 4 as quantified by manual muscle test (MMT) 36 or above * ability to stand without support with eyes closed for 30 s or more * Veterans in the control group will be recruited from the SVAMC and surrounding community using printed advertisements

Design outcomes

Primary

MeasureTime frameDescription
Virtual Environment TBI System (VETS) Assessment of Static PosturographyPre-Surgery compared to otherwise healthy VeteransThe postural stability task involves six conditions during which Veterans are instructed to look straight ahead and maintain an upright stance as stably as possible. Veterans are barefooted with feet comfortably placed \ 25 cm apart. The six conditions are (1) Eyes Open (EO) Firm (2) Eyes Closed (EC) Firm, (3) Dynamic Scene (DYN) Firm, (4) EO Foam, (5) EC Foam, and (6) DYN Foam. a) Comparison of CSM vs. Control and within-subject visual (EO,EC, and DYN) and surface conditions (FIRM and FOAM). b) Comparison of balance and posture at Pre-surgery for CSM group to age and gender matched non-CSM controls. Only pre-surgery data in CSM group was collected due to COVID-19.
Change in Static Posturography (VETS)Pre-surgery compared to 2 weeks, 6 weeks, and 6 months post-surgery VETS factors. The Post-surgery endpoints are normally scheduled clinical follow ups.The Pre-surgery CSM group recruited for VETS (Static Posturography) measurement will also serve as the sample for the change in VETS measurement as a change in centimeters (cm). This is a longitudinal assessment of balance following surgical intervention for CSM.

Secondary

MeasureTime frameDescription
Short Form-36 Version 2 (SF-36v2)PreSurgery compared to otherwise healthy VeteransThe SF-36 questionnaire consists of eight scales yielding two summary measures: physical and mental health. The physical health measure includes four scales of physical functioning (10 items), role-physical (4 items), bodily pain (2 items), and general health (5 items). The mental health measure is composed of vitality (4 items), social functioning (2 items), role-emotional (3 items), and mental health (5 items). The SF-36 offers a choice of recall format at a standard (4 week) or acute (1 week) time frame. Likert scales and yes/no options are used to assess function and well-being on this 36-item questionnaire. To score the SF-36, scales are standardized with a scoring algorithm or by the SF-36v2 scoring software to obtain a score ranging from 0 to 100. Higher scores indicate better health status, and a mean score of 50 has been articulated as a normative value for all scales.
EC FIRM/EO FIRM RatioPreSurgeryFrom the VETS, a ratio corresponding to the Rhomberg ratio of COP sway will be used to determine the degree static posture depends on visual input. The Romberg test used in posturography compares postural sway in eyes open (EO) and eyes closed (EC) conditions. The Romberg ratio was calculated in the traditional manner, i.e. EC/EO. The ensuing Romberg ratio (EC/EO) is used to assess visual dependency in postural stability. Higher Romberg ratios reflect greater instability with closed eyes, ( a greater amount of postural sway during eyes closed) whereas a ratio \< 1 indicates higher stability in the EC versus EO condition.
EO FOAM/EO FIRMPreSurgery compared to otherwise healthy VeteransFrom the VETS, a ratio of COP sway will be used to determine the degree static posture is affected by reduced proprioception.
Nurick ScalePreSurgery compared to otherwise healthy VeteransThe Nurick scale is a 6-grade ordinal scale assessing gait impairment, with grades ranging from 0 (signs and symptoms of root involvement but no evidence of spinal cord disease) to 5 (chair bound or bedridden). The aggregate value of the Nurick scale will be related to posturography. Classification Scheme: * Grade 0: signs or symptoms of root involvement but without evidence of spinal cord disease * Grade 1: signs of spinal cord disease but no difficulty in walking. * Grade 2: slight difficulty in walking which does not prevent full-time employment * Grade 3: difficulty in walking which prevented full time employment or the ability to do all housework, but which was not so severe as to require someone else's help to walk * Grade 4: able to walk only with someone else's help or with the aid of a frame. * Grade 5 : chairbound or bedridden.
DYN FOAM/DYN FIRM RatioPostSurgery compared to otherwise healthy Veterans compared to otherwise healthy VeteransFrom the VETS, a ratio of COP sway will be used to determine how roll vection is induced by loss of proprioception.
DYN FIRM/ EO FIRM RatioPreSurgery compared to otherwise healthy VeteransFrom the VETS, a ration of COP sway to determine the degree roll vection is induced.
EC FOAM/EO FOAM RatioPreSurgery compared to otherwise healthy VeteransFrom the VETS, a ratio of COP sway will be used to determine the degree of loss of visual information. Loss of visual information compounds reduced proprioceptive ability in static balance.
Neck Disability Index (NDI)PreSurgery compared to otherwise healthy VeteransNDI is related to VETS posturography to determine sensitivity of standing posture to degree of disability. The NDI is a 10-item questionnaire addressing function activities (personal care, lifting, reading, work, driving, sleeping, and recreation), pain intensity, concentration, and headache. For each item, patients make their ratings on a 6-point Likert scale with values 0 = no disability and 5 = complete disability. Summed scores for each category are multiplied by 2 to give a total NDI score ranging from 0-100. Score: /50 Transform to percentage score x 100 = %points. Scoring: Example:16 (total scored)50 (total possible score) x 100 = 32% If one section is missed or not applicable the score is calculated: 16 (total scored)45 (total possible score) x 100 = 35.5% Minimum Detectable Change (90% confidence): 5 points or 10 %points

Countries

United States

Participant flow

Recruitment details

Recruitment was significantly hampered by COVID-19 and research shut-downs. Myelopathy surgeries were significantly limited because of COVID as well. Participants were recruited from the pool of eligible individuals undergoing surgery for myelopathy in the Syracuse VA. Recruitment occurred between 2/7/19 and 7/26/22

Pre-assignment details

This did not occur

Participants by arm

ArmCount
Cervical Spondylotic Myelopathy (CSM) Group
Veterans with CSM. CSM is degenerative cervical myelopathy, encapsulates a cascade of events leading to significant degenerative changes in discs, formation of osteophytes, facet hypertrophy, calcification of the posterior longitudinal ligament and ligamentous flavum with resultant canal stenosis and segmental instability.
6
Total6

Withdrawals & dropouts

PeriodReasonFG000
Overall StudyCOVID shut down2

Baseline characteristics

CharacteristicCervical Spondylotic Myelopathy (CSM) Group
Age, Continuous63 years
STANDARD_DEVIATION 3.75
Race and Ethnicity Not Collected— Participants
Region of Enrollment
United States
6 Participants
Sex: Female, Male
Female
0 Participants
Sex: Female, Male
Male
6 Participants

Adverse events

Event typeEG000
affected / at risk
deaths
Total, all-cause mortality
0 / 8
other
Total, other adverse events
0 / 8
serious
Total, serious adverse events
0 / 8

Outcome results

Primary

Change in Static Posturography (VETS)

The Pre-surgery CSM group recruited for VETS (Static Posturography) measurement will also serve as the sample for the change in VETS measurement as a change in centimeters (cm). This is a longitudinal assessment of balance following surgical intervention for CSM.

Time frame: Pre-surgery compared to 2 weeks, 6 weeks, and 6 months post-surgery VETS factors. The Post-surgery endpoints are normally scheduled clinical follow ups.

Population: Subjects were gradually lost to follow-up, leading to a decline in the number of participants analyzed in later sessions.

ArmMeasureGroupValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EO Firm 6Weeks7.2 CMStandard Deviation 9.8
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EC Firm 6Weeks15.6 CMStandard Deviation 22.1
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)DYN Firm 6Weeks15.4 CMStandard Deviation 15.1
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EC Firm 6Months12 CMStandard Deviation 15.1
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EC Foam 6Weeks37.6 CMStandard Deviation 31
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EO Firm PreOp11 CMStandard Deviation 27.1
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EC Firm PreOp13 CMStandard Deviation 15.4
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)DYN Firm PreOp48.4 CMStandard Deviation 51.1
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EO Foam PreOp19.1 CMStandard Deviation 20.3
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EC Foam PreOp44 CMStandard Deviation 32.7
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)DYN Foam PreOp70.7 CMStandard Deviation 47.7
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EO Firm 2Weeks5.6 CMStandard Deviation 4.3
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EC Firm 2Weeks9.4 CMStandard Deviation 8.5
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)DYN Firm 2Weeks11.2 CMStandard Deviation 7
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EO Foam 2Weeks9.8 CMStandard Deviation 7
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EC Foam 2Weeks44.3 CMStandard Deviation 28.7
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)DYN Foam 2Weeks63.5 CMStandard Deviation 39.6
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EO Foam 6Weeks12.2 CMStandard Deviation 7.5
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)DYN Foam 6Weeks88.5 CMStandard Deviation 68.7
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EO Firm 6Months5 CMStandard Deviation 5.4
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)DYN Firm 6Months24.7 CMStandard Deviation 33.8
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EO Foam 6Months13.5 CMStandard Deviation 6.1
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)EC Foam 6Months41.4 CMStandard Deviation 19.1
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Change in Static Posturography (VETS)DYN Foam 6Months62.9 CMStandard Deviation 38.1
Primary

Virtual Environment TBI System (VETS) Assessment of Static Posturography

The postural stability task involves six conditions during which Veterans are instructed to look straight ahead and maintain an upright stance as stably as possible. Veterans are barefooted with feet comfortably placed \ 25 cm apart. The six conditions are (1) Eyes Open (EO) Firm (2) Eyes Closed (EC) Firm, (3) Dynamic Scene (DYN) Firm, (4) EO Foam, (5) EC Foam, and (6) DYN Foam. a) Comparison of CSM vs. Control and within-subject visual (EO,EC, and DYN) and surface conditions (FIRM and FOAM). b) Comparison of balance and posture at Pre-surgery for CSM group to age and gender matched non-CSM controls. Only pre-surgery data in CSM group was collected due to COVID-19.

Time frame: Pre-Surgery compared to otherwise healthy Veterans

Population: COVID facility entry restrictions at the Syracuse VA Medical Center prevented the recruitment of participants who were not already coming to the VA for medical appointments.

ArmMeasureGroupValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Virtual Environment TBI System (VETS) Assessment of Static PosturographyEO Firm11 Square CentimetersStandard Deviation 27.1
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Virtual Environment TBI System (VETS) Assessment of Static PosturographyEC Firm13.0 Square CentimetersStandard Deviation 15.4
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Virtual Environment TBI System (VETS) Assessment of Static PosturographyDYN Firm48.4 Square CentimetersStandard Deviation 51.1
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Virtual Environment TBI System (VETS) Assessment of Static PosturographyEO Foam19.1 Square CentimetersStandard Deviation 20.3
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Virtual Environment TBI System (VETS) Assessment of Static PosturographyEC Foam44 Square CentimetersStandard Deviation 32.7
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Virtual Environment TBI System (VETS) Assessment of Static PosturographyDYN Foam70.7 Square CentimetersStandard Deviation 47.7
Secondary

DYN FIRM/ EO FIRM Ratio

From the VETS, a ration of COP sway to determine the degree roll vection is induced.

Time frame: PreSurgery compared to otherwise healthy Veterans

Population: Could not recruit controls due to COVID restrictions

ArmMeasureValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)DYN FIRM/ EO FIRM Ratio6.49 COP Sway ratioStandard Deviation 6.62
Secondary

DYN FOAM/DYN FIRM Ratio

From the VETS, a ratio of COP sway will be used to determine how roll vection is induced by loss of proprioception.

Time frame: PostSurgery compared to otherwise healthy Veterans compared to otherwise healthy Veterans

Population: Could not recruit controls due to COVID restrictions. Only 4 CSM participants were analyzed compared to the 6 anticipated due to data capture failure in 2 participants during DYN Foam condition and facility entrance policies restricted patient flow for the remainder of the study. Three of them had incomplete trial sessions, but this does not affect overall calculation as this was taken into consideration.

ArmMeasureValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)DYN FOAM/DYN FIRM Ratio8.7 COP Sway ratioStandard Deviation 13.76
Secondary

EC FIRM/EO FIRM Ratio

From the VETS, a ratio corresponding to the Rhomberg ratio of COP sway will be used to determine the degree static posture depends on visual input. The Romberg test used in posturography compares postural sway in eyes open (EO) and eyes closed (EC) conditions. The Romberg ratio was calculated in the traditional manner, i.e. EC/EO. The ensuing Romberg ratio (EC/EO) is used to assess visual dependency in postural stability. Higher Romberg ratios reflect greater instability with closed eyes, ( a greater amount of postural sway during eyes closed) whereas a ratio \< 1 indicates higher stability in the EC versus EO condition.

Time frame: PreSurgery

ArmMeasureValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)EC FIRM/EO FIRM Ratio1.56 COP sway ratioStandard Deviation 1.03
Secondary

EC FOAM/EO FOAM Ratio

From the VETS, a ratio of COP sway will be used to determine the degree of loss of visual information. Loss of visual information compounds reduced proprioceptive ability in static balance.

Time frame: PreSurgery compared to otherwise healthy Veterans

Population: Could not recruit controls due to COVID restrictions

ArmMeasureValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)EC FOAM/EO FOAM Ratio8.43 COP sway ratioStandard Deviation 11.8
Secondary

EO FOAM/EO FIRM

From the VETS, a ratio of COP sway will be used to determine the degree static posture is affected by reduced proprioception.

Time frame: PreSurgery compared to otherwise healthy Veterans

Population: The investigators could not recruit controls due to COVID restrictions

ArmMeasureValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)EO FOAM/EO FIRM2.92 COP sway ratioStandard Deviation 3.17
Secondary

Neck Disability Index (NDI)

NDI is related to VETS posturography to determine sensitivity of standing posture to degree of disability. The NDI is a 10-item questionnaire addressing function activities (personal care, lifting, reading, work, driving, sleeping, and recreation), pain intensity, concentration, and headache. For each item, patients make their ratings on a 6-point Likert scale with values 0 = no disability and 5 = complete disability. Summed scores for each category are multiplied by 2 to give a total NDI score ranging from 0-100. Score: /50 Transform to percentage score x 100 = %points. Scoring: Example:16 (total scored)50 (total possible score) x 100 = 32% If one section is missed or not applicable the score is calculated: 16 (total scored)45 (total possible score) x 100 = 35.5% Minimum Detectable Change (90% confidence): 5 points or 10 %points

Time frame: PreSurgery compared to otherwise healthy Veterans

Population: The investigators did not recruit any controls as we could not run participants who did not already have a clinical appointment, due to COVID restrictions

ArmMeasureValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Neck Disability Index (NDI)59.5 Units on a scaleStandard Deviation 17.5
Secondary

Nurick Scale

The Nurick scale is a 6-grade ordinal scale assessing gait impairment, with grades ranging from 0 (signs and symptoms of root involvement but no evidence of spinal cord disease) to 5 (chair bound or bedridden). The aggregate value of the Nurick scale will be related to posturography. Classification Scheme: * Grade 0: signs or symptoms of root involvement but without evidence of spinal cord disease * Grade 1: signs of spinal cord disease but no difficulty in walking. * Grade 2: slight difficulty in walking which does not prevent full-time employment * Grade 3: difficulty in walking which prevented full time employment or the ability to do all housework, but which was not so severe as to require someone else's help to walk * Grade 4: able to walk only with someone else's help or with the aid of a frame. * Grade 5 : chairbound or bedridden.

Time frame: PreSurgery compared to otherwise healthy Veterans

Population: The investigators did not recruit any controls as we could not run participants who did not already have a clinical appointment, due to COVID restrictions

ArmMeasureValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Nurick Scale2 Units on a scaleStandard Deviation 0.89
Secondary

Short Form-36 Version 2 (SF-36v2)

The SF-36 questionnaire consists of eight scales yielding two summary measures: physical and mental health. The physical health measure includes four scales of physical functioning (10 items), role-physical (4 items), bodily pain (2 items), and general health (5 items). The mental health measure is composed of vitality (4 items), social functioning (2 items), role-emotional (3 items), and mental health (5 items). The SF-36 offers a choice of recall format at a standard (4 week) or acute (1 week) time frame. Likert scales and yes/no options are used to assess function and well-being on this 36-item questionnaire. To score the SF-36, scales are standardized with a scoring algorithm or by the SF-36v2 scoring software to obtain a score ranging from 0 to 100. Higher scores indicate better health status, and a mean score of 50 has been articulated as a normative value for all scales.

Time frame: PreSurgery compared to otherwise healthy Veterans

Population: Healthy controls could not be recruited because of COVID restrictions

ArmMeasureValue (MEAN)Dispersion
Pre-surgical Group: Cervical Spondylotic Myelopathy (CSM)Short Form-36 Version 2 (SF-36v2)44.1 Units on a scaleStandard Deviation 21.1

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026