Effect of Degranulation Needle With Different Diameters on the Rate Good Embryo in IVF

Effect of Degranulation Needle on the Rate Good Embryo in IVF

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03810040

Enrollment

400

Registered

2019-01-18

Start date

2019-02-28

Completion date

2019-11-30

Last updated

2019-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Embryo

Keywords

Embryos quality, In vitro fertilization, Denuding pipette

Brief summary

Good-quality embryos are critical for the success of in vitro fertilization (IVF). But, to date, there is no report of the effect of different diameters denuding pipette on the embryos quality. To investigate the effect of denuding pipette in IVF outcomes, we plan to recruit women undergoing IVF treatment cycles and classified them into two groups according to the different diameters. Consequently, the rate of fertilization, zygotes cleaved, top quality embryos on D3, and blastocysts obtained were recorded.

Detailed description

Good-quality embryos are critical for the success of in vitro fertilization (IVF). But, to date, there is no report of the effect of different diameters denuding pipette on the embryos quality. To investigate the effect of denuding pipette in IVF outcomes, we plan to recruit women undergoing IVF treatment cycles and classified them into two groups according to the different diameters. The participants were divided into two group. Odd-numbered days the zygotes were degranulated with the 140 microns needles. Even-numbered days the zygotes were degranulated with the 150 microns needles. Consequently, the rate of fertilization, zygotes cleaved, top quality embryos on D3, and blastocysts obtained were recorded.

Interventions

DEVICE140 microns denuding pipette

the degranulated needle size was 140 microns

DEVICE150 microns denuding pipette

the degranulated needle size was 150 microns

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

22 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* first cyele of IVF treatment

Exclusion criteria

* oocyte number less than 4 * oocyte number over than 25

Design outcomes

Primary

Measure	Time frame	Description
quality of embryo	one year	embryo quality assessed by good embryo rate

Secondary

Measure	Time frame	Description
clinical outcome - clinical prengancy rate	three years	clinical prengancy rate

Countries

China

Contacts

Primary Contactwang ming

wangmingbio@snnu.edu.cn8613259809290

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026