The Potential of Sperm Retrieved by Micro-TESE to Fertilize Vitrified/Warmed Oocytes

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03809026

Enrollment

100

Registered

2019-01-18

Start date

2015-09-01

Completion date

2024-06-30

Last updated

2023-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Azoospermia, Nonobstructive

Keywords

Azoospermia, micro-TESE, Klinefelter's syndrome, Cryptorchidism, Vitrified oocytes

Brief summary

Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are included. The women are stimulated with FSH in IVF protocols and the aspirated oocytes vitrified with usual applied techniques. Fresh sperm retrieved by micro-TESE are used for fertilization of the warmed oocytes. when it is not possible to obtain testicular sperm, the couples are offered fertilization with warmed oocytes. Fertilization, cleavage, implantation and pregnancy rates using sperm from the patients versus from sperm donors will be compared.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to 100 Years

Inclusion criteria

Couples referred for micro-TESE

Exclusion criteria

None

Design outcomes

Primary

Measure	Time frame	Description
Pregnancy rate	six years	Measurement of serum-hCG and ultrasonography at gestation age week 7
Fertilization rate	six years	Measurement of % of fertilization among the warmed oocytes
Cleavage rate	six years	Measurement of % of cleavage among the warmed oocytes

Secondary

Measure	Time frame	Description
Implantation rate	six years	Measurement of the % of transferred embryos implanting into the uterus

Countries

Denmark

Contacts

Primary ContactJens Fedder, MD, PhD

fedder@dadlnet.dk+45 26820368

Outcome results