Endothelial Dysfunction
Conditions
Keywords
antioxidants, polyphenols, flow-mediated dilatation
Brief summary
High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress. Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.
Interventions
Sponsors
University of the Highlands and Islands
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Females to be postmenopausal and not on hormone replacement therapy * 25 \> BMI \< 35 * Sedentary to light activity lifestyle.
Exclusion criteria
* History of cardiovascular disease (Hypertension, Atherosclerosis, endothelial issues etc). * History of diabetes (Type 1 or type 2) * Vegan or with food allergies or intolerances. * Taking any antioxidants over the counter (Vit C, E or polyphenol supplements) * Taking prescription medication for hypertension.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelial (dys)function | 2 hours post-prandial | Assessed via flow mediated dilatation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma Nitrite | 2 hours post-prandial | — |
| Plasma antioxidant capacity | 2 hours post-prandial | Plasma oxygen radical absorbance capacity |
| Plasma ox-LDL | 2 hours post-prandial | — |
Countries
United Kingdom
Outcome results
None listed