Vancomycin
Conditions
Brief summary
The aim of this study was to assess factors that may influence vancomycin trough level and the rate achieving the target trough level in critically ill patients.
Detailed description
This retrospective observational study included adult patients treated with intravenous vancomycin in intensive care unit of Zhongda Hospital from January 2015 to December 2017. Vancomycin dose was based on international consensus and adjusted according to estimated glomerular filtration rate (eGFR) calculated by the Cockcroft-Gault equation. vancomycin trough level (VTL) was retained at steady state (after the third dose). Linear regression was performed to determine the correlation between factors prior to the first vancomycin dose and VTL. Distribution of VTL and percentage of patients achieving the target trough level (15-20mg/L) was observed in different renal function.
Interventions
DRUGVancomycin
adult patients treated with intravenous vancomycin in intensive care unit
Sponsors
Southeast University, China
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult ICU patients (age≥18 years) treated with intravenous vancomycin were included
Exclusion criteria
* Chronic renal dysfunction and acute renal injury patients treated with Renal Replacement therapy * VTL was not retained at steady-state * Vancomycin treatment time≤48h * Vancomycin dose did not meet study definitions * Palliative care
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of patients achieving the target vancomycin trough（15-20mg/L） | 3 years | Vancomycin trough level was retained at steady state (after the third dose). If a patient has multiple measurements of vancomycin trough level, the first measurement is collected.Rate of patients achieving the target trough level (15-20mg/L) was observed. |
Outcome results
None listed