Cerebral Desaturation and Postoperative Dysfunction After Thoracic Surgery

Cerebral Desaturation During One Lung-ventilation and Postoperative Dysfunction Afterthoracic Surgery: a Prospective Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03805880

Enrollment

100

Registered

2019-01-16

Start date

2018-01-01

Completion date

2018-07-31

Last updated

2019-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Dysfunction, Thoracic Surgery

Brief summary

The purpose of this study prospective observational study is to determine cognitive dysfunction incidence after thoracic surgery. We also evaluate evaluate the role of cerebral oxygen desaturations and hypertension as risk factors for post-operative cognitive dysfunction (POCD) in patients undergoing lung resection.

Interventions

DIAGNOSTIC_TESTcerebral desaturation monitoring and cognitive examination

Before general anesthesia, continuous monitoring of cerebral oxygenation(rSO2) was started using an INVOS 5100 (Somaneic, Tro, MI) .Patient cognitive function was assessed using Mini-Mental State Examination (MMSE) on the day before surgery (baseline) and then after 1 day after surgery.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients scheduled for elective lobectomy or wedge resection via thoracotomy * one lung ventilation (OLV duration) ≥ 45 min

Exclusion criteria

* previous cerebral disease, * dementia, * severe cognitive dysfunction * emergency surgery * pregnancy * patient refusal to give consent * inability to give consent * age ≤18 years * ASA ≥ IV.

Design outcomes

Primary

Measure	Time frame	Description
incidence of cognitive dysfunction after thoracic surgery	change of MMSE score from the day before surgery (baseline) at 1 day after surgery	A decrease in Mini-Mental State Examination (MMSE) score \> 2 points from baseline was defined as Postoperative cognitive dysfunction (POCD)

Secondary

Measure	Time frame	Description
role of cerebral oxygen desaturations as risk factors for POCD in patients undergoing lung resection.	change of cerebral saturation from baseline(before surgery) at intraoperative measure	monitoring values of cerebral saturation during intraoperative period:Cerebral desaturation was defined as a reduction of rSO2 during OLV of more than 20% from the baseline value
role of hypertension as risk factors for POCD in patients undergoing lung resection.	change of blood pressure from baseline(before surgery) at intraoperative measure	monitoring values of blood pressure during intraoperative period

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026