Dyslipidemias, Gallstone
Conditions
Brief summary
Gallbladder disease is one of the most common diseases of the gastrointestinal tract. Various studies have shown an association between gallstones and an alteration in the serum lipids. The objective of this study will be to compare serum lipid profile of gallstone patients with the controls.
Detailed description
This prospective cross-sectional study will be conducted in the Surgical Department of the Services Institute of Medical Sciences. A total of 50 patients will beincluded in the study after screening through the inclusion criteria. A control group of 50 inpatients with no personal or family history of gallstones will be also recruited for comparison. Results will be expressed as mean with standard deviation. Students t- test will be used to compare the data between the patients and the control groups (p\<0.05 will be considered statistically significant). SPSS software, version 20 will be used for statistical analysis.
Interventions
DIAGNOSTIC_TESTSerum lipid profile
Blood samples drawn from the patients and controls will be analyzed for serum cholesterol, serum triglycerides, serum LDLs and serum HDL levels. All the results will be recorded on a performa
Sponsors
Services Hospital, Lahore
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Inclusion criteria
* Male or female patients with the gall stone disease * Age from 20 to 70 years * Gallstones were diagnosed through the ultrasound
Exclusion criteria
* Patients with acalculous gallbladder disease on ultrasound, * Patients with terminal ileal resection, * Patients with hemolytic diseases (hereditary spherocytosis, sickle cell anemia on history and CBC film), * Patients with liver cirrhosis (on abdominal ultrasound) and * Patients on antihyperlipidemic drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum cholesterol levels | 1 week | serum cholesterol levels of patients and case group will be compared with Students t- test was (p\<0.05 will be considered statistically significant) |
| serum triglyceride levels | 1 week | serum triglyceride levels of gallstone patients and control group will be compared via student t-test (p\<0.05 was considered statistically significant) |
| serum HDL levels | 1 week | serum HDL levels of patients and contoled will be compared with student t-test (p\<0.05 was considered statistically significant) |
| serum LDL leves | 1 week | serum LDL leves of patients and control will be compared through student t-test (p\<0.05 was considered statistically significant) |
Countries
Pakistan
Outcome results
None listed