Renal Failure
Conditions
Brief summary
Little knowledge exist on the short and long-term ophthalmological effect of the dialysis. Some studies stated a variation of the thickness subfoveal choroidal before and after a session of dialyse as well as variations of the coat of optical fibers measured in OCT. The Optical Coherence Tomography angiography OCT is a not invasive imaging technique which is now a part of examinations of investigation in imaging of retina. This technique allows to study the retinal macula vascularization without injection of contrast agent and thus allows to deepen the knowledge in medical domains where the exploration was to limited because of the invasive character of the examinations. The hypothesis of this project is that hemodynamic change during the hemodialysis may lead fine variations of the retinal vascularization in the short-term (the day of the dialysis) but also in the longer term (over 1 year).
Interventions
OTHERMultimodal Imaging Analysis
The patients are seen in consultation ophthalmological before and the 1 hour after their session of dialysis. THE OCT angiography and other not invasive ophthalmological examinations will be realized during the follow-up
Sponsors
Centre Hospitalier Intercommunal Creteil
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Indication of treatment by hemodialysis * First session of dialysis * Hemodialysis planned for 1 minimum year
Exclusion criteria
* particular ophthalmological Histories: vitreo-retinal surgery, strong nearsightedness, chronic glaucoma * Unaffiliated in a national insurance scheme
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| vascular density before hemodialysis | before hemodialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm |
| vascular density 1 hour after hemodialysis | 1 hour after hemodialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| vascular density 6 month after dialysis | 6 month after dialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm |
| vascular density 12 month after dialysis | 12 month after dialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm |
| vascular density before dialysis | before dialysis | mesure by OCTA |
| vascular density 1 hour after dialysis | 1 hour after dialysis | mesure by OCTA |
| size of coat retinal optical fibers before dialysis | before dialysis | variation of the coat |
| vascular density 1 month after dialysis | 1 month after dialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm |
| size of coat retinal optical fibers 1 month after dialysis | 1 month after dialysis | variation of the coat |
| size of coat retinal optical fibers 3 month after dialysis | 3 month after dialysis | variation of the coat |
| size of coat retinal optical fibers 6 month after dialysis | 6 month after dialysis | variation of the coat |
| size of coat retinal optical fibers 12 month after dialysis | 12 month after dialysis | variation of the coat |
| size of coat retinal optical fibers 1 hour after dialysis | 1 hour after dialysis | variation of the coat |
| vascular density 3 month after dialysis | 3 month after dialysis | Analysis of the variation of the vascular densities in retinal macula in the central 6 mm |
Countries
France
Outcome results
None listed