Skip to content

The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant in Anterior Region

The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant Placement in Anterior and Premolar Region in Systemically Healthy Patients

Status
UNKNOWN
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03804177
Enrollment
24
Registered
2019-01-15
Start date
2019-02-10
Completion date
2022-04-30
Last updated
2019-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immediate Dental Implant

Keywords

immediate implant, hyaluronic acid, melatonin, vitamin C

Brief summary

The concept of immediate implant placement at the time of tooth extraction was first introduced by Schulte et al. on animal studies. Since then, many follow-up studies examining different variables have supported the concept of immediate implant placement. pioneered a major contribution to immediate implant placement in human studies which recommended the insertion of an implant into a fresh extraction socket. They advocated immediate implant placement primarily to reduce the number of surgical interventions needed to perform an implant-supported rehabilitation and shorten the treatment time. Placement of implants immediately into extraction sites allow the surgeon to idealize the position of the implant appropriately with a better rehabilitation of the normal contour to the facial aspect of the final restoration. Immediate implant placement in fresh extraction sockets was reported to reduce alveolar bone resorption. Better esthetic outcomes were achieved including the prosthetic crown length in harmony with the adjacent teeth, natural scalloping and easier distinct papillae to achieve and maximum soft tissue support. Hyaluronic acid is a glycosaminoglycan, this unique molecule is implicated In a variety of biological functions including structural integrity, and the regulation of embryologic development. It is described as a natural organic substance, with physiological therapy activity, main component of the extracellular matrix of many tissues such as the skin, synovial joints and periodontal tissues .

Interventions

PROCEDUREimmediate implant placement with melatonin hyaluronic acid vit C

immediate implant placement with melatonin and hyaluronic acid and systemic administration vitamin C

PROCEDUREimmediate implant placement without melatonin hyaluronic acid vit C

immediate implant placement without melatonin and hyaluronic acid and systemic administration vitamin C

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)

Masking description

single blinded

Intervention model description

it is randomized clinical trial

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. Age: 18-60. 2. Systemically healthy patients indicated for single or multiple immediate implants in anterior and premolar region. 3. Absence of any peri-apical pathosis. 4. Patients with intact buccal plate of bone. 5. Patients with adequate bone volume for the dental implant procedure. 6. Patient consent approval and signing.

Exclusion criteria

* 1\. Smokers. 2. Systemic disease that may affect the final outcome of the surgical procedure. 3\. No or poor patient's compliance. 4. Patients with psychological problems. 5. Pathology at the site of intervention. 6. Pregnant patients. 7. Patients refuse to sign an informed consent.

Design outcomes

Primary

MeasureTime frameDescription
implant stability6 monthsimplant stability by ostell

Secondary

MeasureTime frameDescription
soft tissue healing6 monthssoft tissue healing by likert scale (0 indicate complete soft tissue Closure (no line of fibrin) , 1 indicate complete closure (thin line of fibrin) , 2 indcate complete closure (fibrin) , 3 indicate in complete closure (dehiscence ) , 4 indicate incomplete closure (necrosis)

Contacts

Primary Contactahmed Nasser, Msc
ahmedelsawi8787@gmail.com00201094959526

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026