Metabolomic Profiling of Eosinophilic Esophagitis

Metabolomic Profiling of Eosinophilic Esophagitis Patients With Dysphagia for Biomarker Discovery

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03803527

Enrollment

Registered

2019-01-14

Start date

2019-12-01

Completion date

2021-08-01

Last updated

2019-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eosinophilic Esophagitis

Brief summary

A prospective longitudinal, observational study of adolescent and adults that will identify novel metabolites associated with dysphagia in Eosinophilic Esophagitis (EoE).

Detailed description

In this study, the investigators seek to understand whether a metabolomic profile obtained from esophageal samples correlate with the symptom of dysphagia in adolescent and adults. The investigators hypothesize that intraluminal secreted metabolite(s) will change during episodes of dysphagia. The aim of the study will be to use a novel method of producing esophageal luminal samples, the esophageal string test, to capture esophageal metabolites when a patient is and is not experiencing dysphagia.

Interventions

PROCEDUREEsophageal String Test

An EST will be performed for a 1hour sampling period on the same day as the scheduled clinic visit. Subjects will be asked to swallow a capsule and the attached EST string will be taped to the cheek with tegaderm tape. At the completion of the 1-hour sampling period, the EST will be removed and it will immediately be processed and cryopreserved for metabolomics profiling.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

11 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Subjects with Eosinophilic Esophagitis (EoE) and seen either at Children's Hospital Colorado or University of Colorado Hospital for scheduled outpatient clinical assessment or upper GI endoscopy

Exclusion criteria

* Acute food impaction at time of study * Recent (within 2 months) use of systemic steroids * Other known esophageal disease or esophageal injury (e.g. tracheoesophageal fistula, congenital stricture, caustic injury) * known other inflammatory bowel disease * inability to swallow the EST

Design outcomes

Primary

Measure	Time frame	Description
Brief Esophageal Dysphagia Questionnaire	Time of Endoscopic Procedure	Positive Dysphagia symptoms Measured by Brief Esophageal Dysphagia Questionnaire. The questionnaire asks questions about dysphagia symptoms and the scale is from 0 (rarely/never) to 5 (several times per day).

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026