Cerebral Embolism
Conditions
Brief summary
During different interventional cardiology procedures we aim to identify cerebral microemboli load. Further we aim to differentiate the quality and the quantity of cerebral microemboli.We will measure cerebral microemboli in different interventional phases, e.g. during valve deployment, rapid pacing, post-implantation.
Interventions
DEVICETranscranial Doppler (TCD) ultrasound measurement
Non-invasive measurement of cerebral embolic load and blood flow using TCD
Sponsors
Insel Gruppe AG, University Hospital Bern
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years * Interventional cardiology procedure (TAVI, MitraClip, TricuspidalClip)
Exclusion criteria
* Allergy to ultrasound gel or materials contained in the TCD probe * Missing temporal bone window
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality of cerebral microemboli (solid vs. gaseous) | intraoperative phase, expected to be approx. 4 hours | The quality of cerebral microemboli is measured by Doppler ultrasonography which automatically detects and analyses the Doppler signal coming from the middle cerebral artery. According to the strength of signal reflection, the signal will be qualified as solid or gaseous. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quantity of cerebral microemboli load | intraoperative phase, expected to be approx. 4 hours | The quantity of cerebral microemboli is measured by Doppler ultrasonography which automatically register the counts of solid and gaseous emboli. |
| Cerebral hemispheric differences (left vs. right) | intraoperative phase, expected to be approx. 4 hours | — |
Countries
Switzerland
Outcome results
None listed