AKI, Sepsis, Sepsis, Severe, Septic Shock
Conditions
Keywords
AKI, Sepsis, Biomarker, renal function, oxidative stress
Brief summary
Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients.
Detailed description
Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Research on AKI has focused on new damage biomarkers for early detection of AKI and worsening of renal function. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining functional and damage markers as well as oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients. Therefore, this prospective, observational study will be conducted in Mainland China
Interventions
None listed
Sponsors
Zhongnan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* sepsis patients in appropriate age
Exclusion criteria
* ever blood transfusion ever CPR（cardiopulmonary resuscitation)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| presence of AKI | a week after admission to ICU | Use serum creatinine or urine output（The KDIGO Guidelines 2012) to asess whether AKI happens to the studied subjects within a week after admission to ICU |
| Death of the patients | 2 weeks after admission to ICU | Mortality of the studied patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Use serum creatinine to assess renal function of the patients | the 1 day when the patients admitted to ICU | Concetration of serum creatinine |
Countries
China
Contacts
Primary Contactzhiyong peng, professor
Backup ContactLi He
Outcome results
None listed