Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation

The Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03801486

Enrollment

Registered

2019-01-11

Start date

2016-03-02

Completion date

2017-05-01

Last updated

2023-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endothelial Dysfunction

Brief summary

The investigators examined the effects on post-digestion brachial artery flow mediated dilation (FMD) and in vitro antioxidant capacity of 40% semolina flour replacement with sprouted chickpea flour.

Detailed description

The purpose of the current study was to examine in-vitro and in-vivo effects of replacing 40% of semolina flour with sprouted chickpea flour for the use in pasta. Antioxidant capacity in-vitro was measured by Trolox Equivalent Antioxidant Capacity. Brachial artery flow-mediated dilation, a test of in-vivo endothelial function, was performed for assessment of effects on post-digestion endothelial function. The investigators hypothesized that FMD would be higher after consuming 40% of semolina flour with sprouted chickpea flour pasta vs. 100% of semolina flour pasta.

Interventions

OTHERExperimental: Sprouted Chickpea Flour

255g of pasta with 40% sprouted chickpea flour and 60% semolina flour (SCF40) with butter.

OTHERControl: Semolina Flour

255g of pasta with 100% semolina flour (SEM100) with butter.

Study design

Observational model

CASE_CROSSOVER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy adult

Exclusion criteria

* have diabetes mellitus, kidney disease, a history of cancer, cardiac issues, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions. * food allergies relevant to wheat, gluten, chickpea, and pasta sauce. * are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases. * are unable or unwilling to refrain from recreational drug (marijuana, cocaine, etc.) or alcohol use during the 24 hours prior to your exercise session. * use nicotine products, or non-contraceptive hormonal therapy (birth control is okay). * are pregnant or trying to become pregnant.

Design outcomes

Primary

Measure	Time frame	Description
Post-digestion flow mediated dilation	Two hours following meal	Post meal

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 20, 2026