Exercise and Overnight Motor Sequence Task

12-week Aerobic-Anaerobic Transition Exercise Intervention and Overnight Sleep-dependent Procedural Memory Consolidation in Patients With Schizophrenia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03800368

Acronym

EOMST

Enrollment

Registered

2019-01-11

Start date

2016-12-21

Completion date

2017-09-01

Last updated

2019-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia and Related Disorders, Psychotic Disorders

Keywords

Exercise, Sleep-dependent memory consolidation, Aerobic, Anaerobic

Brief summary

The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.

Interventions

OTHERExercise

Indoor cycling exercise intervention

OTHERNon-exercise

Psycho-education

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Inclusion criteria

* Aged from 18 to 55 * Based on the SCID diagnosed to have schizophrenia and related psychotic disorders * Ability to understand the nature of the study and to give written informed consent

Exclusion criteria

* Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders * Comorbid substance dependence * Unstable psychotic symptoms * A history of brain trauma or organic brain disease * Known history of intellectual disability or special school attendance * Answered one or more yes in the PAR-Q and without doctors approval for exercise

Design outcomes

Primary

Measure	Time frame	Description
The sleep-dependent procedural memory consolidation after 12 weeks of intervention	12-week Follow-up	Tested by comparing the finger-tapping motor sequence task performance between the three groups during the 12-week follow-up assessment.

Secondary

Measure	Time frame	Description
The verbal memory consolidation after 12 weeks of intervention	12-week Follow-up	Tested by comparing the logical memory task performance between the three groups during the 12-week follow-up assessment
The attention performance after 12 weeks of intervention	12-week Follow-up	Measured by using the cancellation task performance and compare between the three groups during the 12-week follow-up assessment
The sleep quality after 12 weeks of intervention	12-week Follow-up	Measured by using the Pittsburgh Sleep Quality Index (PSQI) and compare the differences between the three groups during the 12-week follow-up assessment
The insomnia severity after 12 weeks of intervention	12-week Follow-up	Measured by using the Insomnia Severity Index (ISI) and compare the differences between the three groups during the 12-week follow-up assessment

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026