Pulmonary Infection
Conditions
Brief summary
Pulmonary infections remain the leading causes of morbidity and mortality among patients worldwide. Pathogen identification is crucial yet difficult for the majority of the cases. Metagenomic Next-generation Sequencing provides a potential technology for rapid and untargeted pathogen detection for pulmonary infection. The study is designed observationally to investigate if mNGS is superior to traditional paradigm of serial tests in the aspect of diagnostic performance. Patients whose primary diagnosis is pulmonary infetion and bronchoalveolar lavage fluid can be obtained will be enrolled. Both mNGS and traditional paradigm of serial tests wil be performed.
Interventions
OTHERNone Intervention
It is observational study
Sponsors
Sir Run Run Shaw Hospital
Study design
Observational model
CASE_ONLY
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Pulmonary infection as the primary diagnosis * Bronchoalveolar lavage fluid can be obtained
Exclusion criteria
* when the primary diagnosis is tumor or connective tissue diseases * microbiological diagnosis is confirmed before bronchoalveolar lavage * not enough bronchoalveolar lavage fluid for mNGS
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| microbiological diagnosis (pathogen of pulmonary infection) | through study completion, up to 6 months | the final microbiological diagnosis (pathogen of pulmonary infection) after using of every detection method and combined with clinical manifestations. |
Countries
China
Outcome results
None listed