Infertility, Female
Conditions
Keywords
Frozen embryo replacement, IVF success, ovarian stimulation
Brief summary
There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer
Detailed description
There has been a recent significant increase in the frozen embryo replacement (FER) cycles due to freeze-all cycles to decrease the risk of ovarian hyperstimulation syndrome. Now a days making frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that: 1. The endometrium in stimulated cycles is not optimal for implantation 2. Pregnancy rates are increased following FET 3. Perinatal outcomes are less affected after FET 4. Preimplantation genetic screening We will follow only natural and modified natural cycles patients. Spontaneous ovulation will documented with hormonal and sonographic monitoring. Hormonal monitoring are including estradiol and luteinizing hormone (LH). Sonographic monitoring is including follicule diameter (16-20 mm). At modified natural cycles we will use hCG triggering for ovulation approximately 16-20 mm diameter. We will compare success rate between natural and modified natural cycles
Interventions
OTHERnatural cycle
When follicle is ready for ovulation, we will use this injection by intra-dermal route
we will use that drug in the natural modified transfer group after embryo transfer
OTHERembryo transfer
we will do transfer when the endometrium is ready
Sponsors
Acibadem University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Patient who are admitted to the IVF center and who will be transferred to frozen embryos. * Infertile women under 40 years of age who accepted this study. * Unexplained infertilite couple. * All ovulatory patient. * Male factor. * Tubal factor.
Exclusion criteria
* Patients who made intrauterin surgery. * Over 40 years of age women. * Patients with preimplantation genetic diagnosis. * Anovulatory patient.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| birth | bigger than 24 weeks pregnancy | live birth |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pregnancy rate | 10th day after embryo transfer | hcg blood test |
| clinical pregnancy rate | 8 weeks | positive fetal cardiac activity |
| abortion rate | 8 weeks | abortion after visualization of fetal cardiac activity |
Countries
Turkey (Türkiye)
Outcome results
None listed