Valvular Heart Disease
Conditions
Brief summary
Aortic valve stenosis (AVS) is becoming more and more frequent with the aging, which has brought a heavy burden to the world. However, the prevalence and prognosis of valvular heart disease are not so clear, especially in the developing countries such as China etc. Because of the slow and progressive nature of AVS, symptoms might not be too severe to be diagnosed on time. Our retrospective survey (Int J Cardiol. 2016 Nov 25) indicated that severe aortic valve stenosis are very common in China. Hence, we design a prospective, observational cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective ,treatments and prognosis of Chinese elderly patients with aortic valve stenosis.
Interventions
OTHEROur study type is observational
Our study type is observational
Sponsors
First Affiliated Hospital of Wenzhou Medical University
Second Affiliated Hospital of Wenzhou Medical University
Jinhua Central Hospital
The Second Affiliated Hospital of Jiaxing University
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
The Central Hospital of Lishui City
Sir Run Run Shaw Hospital
Ningbo Medical Center Lihuili Hospital
Ningbo No. 1 Hospital
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1\. Patients over 60 years old meet the following condition moderate or above aortic stenosis as defined by echocardiography: Aortic stenosis, moderate or above, or valve area≤1.5cm2, or maximal jet velocity ≥3.0m/sec, or mean pressure gradient≥20mmHg
Exclusion criteria
1. Patients cannot be followed up for any reasons. 2. Patients in critical condition may be die in one year. 3. Patients have been enrolled in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality,disabling strokes and Surgical or transcatheter aortic valve replacement | one year | time from enrolled to first occurrence of any of the components of the composite outcome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospitalization for heart failure | one year | time from enrolled to first occurrence of the outcome |
| Surgical or transcatheter aortic valve replacement | one year | time from enrolled to first occurrence of the outcome |
| Cardiovascular death | one year | time from enrolled to first occurrence of the outcome |
Countries
China
Outcome results
None listed