Immunologic Activity Alteration, Preterm Birth
Conditions
Brief summary
This study investigates immunological and clinical markers in threatened preterm birth aiming to create a prediction model for preterm birth.
Detailed description
Preterm birth is the main cause of neonatal mortality and morbidity and despite a lot of effort the mechanisms leading to preterm birth are poorly understood. In threatened preterm birth it is difficult to identify the true high risk cases ultimately leading to preterm birth. These women are often overtreated. In this study blood samples are taken from women with threatened preterm birth and from women with normal pregnancies before and during labor. Differences in clinical characteristics and immunological markers between the groups are studied in order to design a prediction model for preterm birth.
Interventions
None listed
Sponsors
Linkoeping University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Threatened preterm birth before 34 weeks of gestation; either threatened preterm labor and/or preterm prelabor rupture of the membranes * Age \> 18 years * Swedish-speaking (understanding study information)
Exclusion criteria
* Multiple gestation * Blood borne infections
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time of delivery | Outcome noted at delivery | Delivery before 34 weeks of gestation or after 34 weeks of gestation |
Outcome results
None listed