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Allium Sativum Extract as an Irrigant

Allium Sativum Extract as an Irrigant in Pulpectomy of Primary Molars: 12 Month In-vivo Study

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03795636
Enrollment
91
Registered
2019-01-08
Start date
2016-10-30
Completion date
2018-08-15
Last updated
2019-10-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infected Root Canals of Primary Molars

Keywords

Primary molars, Garlic extract, Sodium hypochlorite, Pulpectomy

Brief summary

Garlic extract as herbal compound has potent antibacterial properties and can be used safely as an irrigant for pulpectomy procedure of primary molars root canals with high clinical and radiographic outcomes

Detailed description

Aim: This study indented to assess the clinical and radiographic assessment of garlic extract as an intracanal irrigant for pulpectomy of primary molars. Methodology: 91 child with 100 teeth submitted into this study were equally categorized into the test group (group 1) which irrigated with garlic extract and control group (group 2) that received sodium hypochlorite (NaOCl). Then, each group has been subjected to further specification according to the tooth preoperative clinical and radiographic features into has been into 2 subgroups. Clinical and radiographic success rates were checked at 3, 6 and 12 months. Fisher's exact test for binary variable was used for data analysis with p-value ≤ 0.05.

Interventions

OTHERGarlic extract

A 100 gram of garlic cloves has been cleaned, peeled and dried. Ethanol of 70% concentration was added for 60 seconds. The cloves were placed in a laminar airflow chamber for evaporation of residual ethanol. Using a sterile mortar and pestle, cloves were homogenized aseptically and filtered through a double layer paper. The fully concentrated extracted was diluted to the concentration of 25% with distilled water

OTHERNaOCl (COLTENE®)

Sodium hypochlorite

Sponsors

Minia University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
4 Years to 6 Years
Healthy volunteers
Yes

Inclusion criteria

1. Class I or II according to American Society of Anesthesiologists (ASA) 2. Irreversible pulpititis recognised through; (1) profuse bleeding from root canal orifices after complete debridement of coronal pulp tissue and cannot be dominated by moist cotton pellet. (2) History of lingered thermal pain spontaneous nocturnal pain 3. Necrotic pulp tissues which may be asymptomatic or manifested with dull ache pain 4. Pathological tooth mobility 5. Percussion sensitivity 6. Swelling close to involved tooth accompanied with or without fistula Radiographic characteristics of the root and supporting structures 1\. Normal radiographic findings 2\. Interruption of lamina dura 3\. Furcation radiolucency

Exclusion criteria

* Specifications of exclusion 1. Uncooperativeness of child and/or parents or caregivers behavior 2. Unrestorable tooth 3. Presence of internal root resorption 4. Presence of calcific metamorphosis inside root canals 5. Presence of root resorption exceeding one third of its length

Design outcomes

Primary

MeasureTime frameDescription
oral examination12 monthsPain assessment using Visual Analog Score for pain
radiographic success or failure12 monthsRadiographic assessment using periapical radiograph and score (0) applied for absence of radiolucency and score (1) for presence of radiolucency

Secondary

MeasureTime frameDescription
Types of failures12 monthsdetecting the percent of different failure types accompanied with pulpectomy procedures after using garlic as an irrigant solution.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026