Multiple Synchronous Lung Cancers (MSLCs)
Conditions
Brief summary
This prospective study is to characterize the genomic landscape and genetic heterogeneity of multiple synchronous lung cancer (MSLC) in correlation with comprehensive clinical, histopathological and medical imaging information, in order to improve disease diagnosis and tailored treatment for MSLC patients.
Detailed description
* To initiate a prospective registry of MSLC patients with high-quality clinical samples and detailed medical data. * To define the clonal relationship, genomic landscape and potential driver alterations of MSLC using whole-genome sequencing. * To determine the intrapatient and intratumor genetic heterogeneity of MSLC. * To correlate molecular features with clinical parameters and patient outcome. * To serve as a continuous infrastructure for a large variety of research purposes including: A. Diagnostic research B. Prognostic research C. Biological research D. Interventional trial design testing new therapies in MSLC.
Interventions
None listed
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 years or older * Confirmed diagnosis of multiple synchronous lung cancers (MSLCs) without metastatic disease * Signed informed consent
Exclusion criteria
* Medical or psychiatric condition that would preclude informed consent * History of known high-risk infections * With metastatic tumors except lung
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genomic characters of synchronous lessions in each MSLC patient | November 30, 2021 | Whole-genome sequencing reveals the mutation, copy number variation and structure variation of MSLCs. We will analysis the genomic characters of synchronous lesions in each MSLC patient. |
Countries
China
Contacts
Primary ContactPengfei Ma, Ph.D.
Outcome results
None listed