Intestinal Microbiota and Antimicrobial Resistance in Hong Kong Residents After Travel

Changes in Intestinal Microbiota and Acquisition of Antimicrobial Resistance in Hong Kong Residents After Travel

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03794479

Enrollment

125

Registered

2019-01-07

Start date

2018-11-05

Completion date

2023-06-06

Last updated

2023-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antimicrobial Resistance

Keywords

Intestinal microbiota, Antimicrobial resistance

Brief summary

International travel is well reported to be associated with acquisition of multidrug-resistant organisms, however, the impact of colonization of these multidrug-resistant organisms is currently uncertain. As colonization of multidrug-resistant organisms had been demonstrated to be associated with distinct intestinal microbiota composition and travellers constitute a generally healthy population with minimal antibiotics exposure; by evaluating serial stool samples before and after travel, the investigators can delineate a potential causal relationship between host intestinal microbiota and subsequent risk of acquisition of multidrug-resistant organisms.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults aged 18 years or above * Chinese ethnicity * Planning to visit any places outside of Hong Kong within the next three months * Able to provide informed consent

Exclusion criteria

* Use of antibiotics within 4 weeks prior to the time of recruitment (Except for antimalarial prophylaxis) * Hospitalization within 3 months * Underlying gastrointestinal diseases, including gastrointestinal malignancy, inflammatory bowel disease, resection of small or large bowel * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Proportion of patients acquiring intestinal colonization of ESBL-producing Enterobacteriaceae	1 year	Intestinal colonization of ESBL-producing Enterobacteriaceae is defined as the presence of ESBL in Enterobacteriaceae identified in the post-travel stool samples, in patients without these organisms detected in their stool samples before travel.

Secondary

Measure	Time frame	Description
Proportion of patients acquiring intestinal colonization of carbapenem-resistant Enterobacteriaceae	1 year	Intestinal colonization of carbapenem-resistant Enterobacteriaceae is defined as the presence of carbapenem-resistant Enterobacteriaceae identified in the stool samples, in patients without these organisms detected in their stool samples before travel.

Countries

Hong Kong

Outcome results