Lung Cancer, Lung Diseases
Conditions
Brief summary
The present study is to evaluate the effect of positive end-expiratory pressure (PEEP) in predicting fluid responsiveness in patients undergoing one-lung ventilation.
Detailed description
Appropriate fluid challenge is crucial during lung surgery under one-lung ventilation. Applying PEEP in mechanically ventilating patients changes dynamic hemodynamic parameters (stroke volume variation, pulse pressure variation), which is more pronounced in hypovolemic patients. The aim of the present study is to evaluate the mechanically ventilating patients under one-lung ventilation requiring fluid resuscitation by applying PEEP to predict fluid responsiveness. The investigators hypothesized that applying PEEP in one-lung ventilating patients can also change dynamic parameters and the magnitude of the change of stroke volume variation, pulse pressure variation can predict fluid responsiveness. The investigator applied PEEP 10 mmHg in one-lung ventilating patients and observed the dynamic parameters including stroke volume variation, pulse pressure variation and then infused 6ml/kg of crystalloid for fluid challenge and diagnosed fluid responsiveness as 10% increase of stroke volume after fluid challenge.
Interventions
PROCEDUREPEEP challenge
apply PEEP 10 mmHg in one-lung ventilating patients.
Sponsors
Hallym University Kangnam Sacred Heart Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing lung surgery under one-lung ventilation
Exclusion criteria
* arrhythmia * moderate to severe valvular heart disease moderate to severe pericardial effusion left ventricular ejection fraction \< 40% * moderate to severe chronic obstructive lung disease * unable to insert oesophageal Doppler Monitor (ODM) probe ( esophageal stent, esophageal cancer, previous esophageal surgery, esophageal stricture, esophageal varices, pharyngeal pouch and severe coagulopathy ) * patient refusal * cannot understand the protocol * less than 50kg or over 100kg in weight
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pulse pressure variation | 5 minutes after PEEP challenge | Temporary increase of PEEP will be able to predict fluid responsiveness using increase of pulse pressure variation over 1%. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| stroke volume variation | 5 minutes after PEEP challenge | Temporary increase of PEEP will be able to predict fluid responsiveness using increase of stroke volume variation over 1%. |
Countries
South Korea
Outcome results
None listed