Chronic Kidney Disease
Conditions
Keywords
body composition, chronic kidney disease, dietary pattern, gut microbiot
Brief summary
This study is aimed to evaluate the impact of dietary pattern, gut microbiota and their interactions on clinical outcomes among patient with CKD stage 3-5.
Interventions
None listed
Sponsors
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Inclusion criteria
* Patients with CKD stage 3-5 defined as eGFR \<60 ml/min/1.73 m2 calculated with the use of the four-variable Modification of Diet in Renal Disease formula who have not yet on dialysis therapy.
Exclusion criteria
* Patients with active cancer * Patients with liver cirrhosis * Patients have taken antibiotics within three months before screening for inclusion. * Patients with a cardiac pacemaker or metallic implants, * Patients are amputees * Pregnant women * Patients with inherited renal diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| renal outcome | 3-year follow-up | a composite of ≥40% decrease in eGFR and ESRD needing chronic dialysis or preemptive kidney transplantation |
| cardiovascular outcome | 3-year follow-up | a composite of major adverse CV events, defined as CV death, myocardial infarction, or ischemic stroke |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| all-cause mortality | 3-year follow-up | CV death or non-CV death |
| neurological outcome | 3-year follow-up | the change of cognitive function or they development of dementia assessed by the Modified Mini-Mental Status Exam annually for 3 years |
Other
| Measure | Time frame | Description |
|---|---|---|
| change of lean body mass, measured by bioimpedance spectroscopy every 3 months for 2 years | 2-year | the change of lean body mass |
Countries
Taiwan
Contacts
Primary ContactTING-YUN LIN
Outcome results
None listed