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The Effect of Unfavorable Histological Features on the Oncological Outcomes of Colon Cancer

The Effect of Unfavorable Histological Features on the Oncological Outcomes of Colon Cancer

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03794193
Enrollment
1367
Registered
2019-01-04
Start date
2016-01-01
Completion date
2023-12-31
Last updated
2022-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Cancer

Brief summary

To explore the effect of unfavorable histological features on the clinical outcomes of patients receiving radical resection of colon cancer.

Interventions

PROCEDURERadical resection of colon cancer

The patients with colon cancer will receive radical surgery. Adjuvant chemotherapy will be given according to the results of postoperative histological results.

Sponsors

Chinese Academy of Medical Sciences
CollaboratorOTHER
West China Hospital
CollaboratorOTHER
Sixth Affiliated Hospital, Sun Yat-sen University
CollaboratorOTHER
Peking University First Hospital
CollaboratorOTHER
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
CollaboratorOTHER
Peking Union Medical College Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No

Inclusion criteria

1. Age: 18-100 years old; 2. Postoperative pathology confirmed colon adenocarcinoma; 3. The tumor is located from the cecum to the sigmoid colon; 4. No distant organ metastasis;

Exclusion criteria

1. Simultaneous or metachronous multiple primary colorectal cancer; 2. History of previous malignant tumors (except for completely cured cervical carcinoma in situ or basal cell carcinoma or squamous epithelial skin cancer) 3. local excision procedure; 4. palliative resection (R2 resection); 5. pregnant or lactating women.

Design outcomes

Primary

MeasureTime frameDescription
3-year Disease-free SurvivalWithin 3 years after surgeryThe time from the time of surgery to the time of recurrence or death from any cause, calculated on a monthly basis, with the most recent recurrence and metastasis.

Secondary

MeasureTime frameDescription
3-year Over-all SurvivalWithin 3 years after surgeryThe time from the time of surgery to the time of recurrence or death from any cause, calculated on a monthly basis.
Postoperative complication rateWithin 30 days after surgery—
Postoperative mortality rateWithin 30 days after surgery—
Local recurrence rateWithin 3 years after surgery—
Distant organ metastasis rateWithin 3 years after surgery—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 8, 2026