Alzheimer Disease, Protection Against, Health Behavior
Conditions
Brief summary
The study investigates whether information on having a risk genotype (ApoE4) and life style advisory information affects lifestyle changes and sensory preferences. The project studies also the ethic aspects of giving the information of risk genotype.
Detailed description
We will run intervention based on our earlier pilot study. It includes intensive intervention and a modification of our earlier pilot intervention. Our intervention methods are general lectures of the effects of healthy diet (Finnish Nutrition Recommendations 2014) and healthy lifestyle for all participants. Effects on motivation, attitudes and preferences will be studied and verified by questionnaires and risk factors of cardiovascular disease and Alzheimer disease by analyzing clinical markers of lipid metabolism, general phenotype markers and profiles of nutritional markers. Nutritional biomarkers will verify also the self-reported changes of diet in the questionnaires and in digital food diaries.
Interventions
BEHAVIORALinformation on the risk gene status
information on risk gene status (APOE4 allele or not) was given before intervention
BEHAVIORALlife style advise
all test persons were given information on healthy diet and life style
Sponsors
University of Turku
University of Eastern Finland
Academy of Finland
Natural Resources Institute Finland
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 40 and 60 years * overall good health (no chronic conditions e.g. mental disorders, cancer, liver or kidney disease, current or previous diagnosis), * body mass index (BMI) under 35 kg/m2, * blood pressure under 140/90 mmHg (medication allowed), * serum total cholesterol under 7.25 mmol/l (medication allowed) * fasting plasma glucose level under 7 mmol/l.
Exclusion criteria
* Abnormal values of the alanine amino transferase, alkaline phosphatase, haptoglobin and thyroid stimulating hormone
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| APOE and BDNF genotype | baseline | — |
| Number of participants with good quality of dietary fat | 2 years | A questionnaire according to Finnish guidelines of Suomen Sydänliitto ry, Helldán & Helakorpi, (2015) |
| Dietary habits, number of participants | 2 years | A questionnaire asking for * Fish intake at least twice per week * Consumption of high fat and sugar foods * Consumption of vegetables * Alcohol consumption * Physical activity at least twice per week |
| Food choice questionnaire, health and taste attitude | 2 years | Scale 1-7 (7 most important, fully agree) |
| Food involvement and Food mavenism, scale 1-5 | 2 years | 5 fully agree |
| Health concern, scale 1-9 | 2 years | 1 not concerned at all |
| Life-orientation test, scale 1-5 | 2 years | 1 fully agree |
| Locus of Control, state-trait anxiety inventory, Three-Factor Eating Questionnaire (TFEQ) scale 1-4 | 2 years | 4 fully agree |
| weight kg | 2 years | — |
| height m | 2 years | — |
| Waist circumference, cm | 2 years | — |
| Visceral fat level (1-30) | 2 years | — |
| blood pressure, mmHg | 2 years | — |
| Serum lipid levels mmol/L | 2 years | — |
| Blood glucose levels, mmol/L | 2 years | — |
| Serum lipid peroxidation, MDA/µM | 2 years | — |
| Serum Sensitive C reactive protein, mg/L | 2 years | — |
| Serum Hemoglobin, g/L | 2 years | — |
| Serum Alkaline phosphatase, U/L | 2 years | — |
| Serum Alanine aminotransferase, U/L | 2 years | — |
| Serum haptoglobin, g/L | 2 years | — |
| Plasma thyrotropin, mU/L | 2 years | — |
| serum APOE protein, mg/L | 2 years | — |
| serum brain-derived neurotrophic factor, ng/ml | 2 years | — |
| serum Fatty acids, g/100g fatty acids | 2 years | — |
| serum Carotenoids, retinol and α-tocopherol, Plasma total phenolics ng/µl | 2 years | — |
| Blood cell count | 2 years | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body mass index | 2 years | weight and height will be combined to report BMI in kg/m\^2 |
Outcome results
None listed