B Lymphocyte Receptor, Immune Repertoire, Ovarian High Grade Serous Carcinoma, T Lymphocyte Receptor
Conditions
Brief summary
In this preliminary study, peripheral blood and carcinoma tissue with pericarcinomatous tissue are taken from the patients with ovarian high grade serous carcinoma at several points: before any treatment, after the debulking surgery, and after all the proposed chemotherapy. The differential expression of the T/B lymphocyte receptors in these samples will be analyzed with the platinum-based treatment and survival outcomes of the patients. The primary objective is the expression rates of T/B lymphocyte receptors in different stages of checking points.
Interventions
PROCEDURETreatment for ovarian cancer
The treatment for ovarian cancer includes the debulking surgery and platinum-based chemotherapy.
Sponsors
Lei Li
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Confirmed of primary ovarian high grade serous carcinoma * Aged 18 years or older * No immunosuppressive disease * Signed an approved informed consents
Exclusion criteria
* Not meeting all of the inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Expression rates of T lymphocyte receptors | One year | Expression rates of T lymphocyte receptors in different stages of checking points, including timings before any treatment, after the debulking surgery, and after all the proposed chemotherapy |
| Expression rates of B lymphocyte receptors | One year | Expression rates of T lymphocyte receptors in different stages of checking points, including timings before any treatment, after the debulking surgery, and after all the proposed chemotherapy |
Countries
China
Contacts
Primary ContactLei Li, M.D.
Outcome results
None listed