Prenatal Alcohol Exposure
Conditions
Keywords
Prenatal alcohol exposure, Emotional, Cognition, Addiction, Fetal Alcohol Syndrome
Brief summary
Hypothesis: Individuals presenting with prenatal alcohol exposure (PEA) show emotional abilities deficits, and imbalance between the two systems involved in decision-making according to dual-process models, namely an under-activated reflective system (involved in deliberate behaviors) and an over-activated affective-automatic one (involved in impulsive behaviors). Primary objective: To explore performance (as a percentage of correct answers) in an emotional facial expression decoding task in PEA participants compared to controls without alcohol disorder.
Detailed description
Each participant will undergo 2 visits : First visit : * Checking inclusion and non-inclusion criteria * Note of information and consent form * Record of concomitant treatments and anamnestic elements * Alcohol, Tobacco, and Toxic Consumption * Urinary Toxicity Test for Control Groups * Laterality test (Hecaen, 1984) * Brief visual and auditory acuity test * Standardized psychiatric interview (Mini International Neuropsychiatric Interview - MINI) Second visit = Experimental testing * State-Trait Anxiety Inventory, Beck Depression Inventory, Inventory of Interpersonal Problems, Toronto Alexithymia Scale (TAS-20). * Participant installation and testing: 6 behavioral tasks on a computer (also used to collect responses, except for task 2, see details below) : Task 1 (MAIN): Test for recognition of facial emotions Task 2: 'Reading the Mind in the Eyes Test' (Decoding of complex emotional states) Task 3: Emotional evaluation of natural scenes Task 4: Target detection (measure of attentional bias towards alcohol-related stimuli) Task 5: Go / No-Go evaluating the interactions between inhibition processes and auto-affective system Task 6: "N-back" evaluating the interactions between working memory and automatic-affective system
Interventions
OTHERFacial Emotion Test
All tasks will be delivered using a laptop and E-Prime 2 software (Psychology Software Tools, Inc., Pittsburgh), which will also be used to collect behavioral responses.
Sponsors
University Hospital, Lille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Man or woman aged between 18 and 60 years * Able to understand and to speak French * Able to understand Note of information and to sign consent form * Available health insurance * Normal (or corrected to normal) vision and audition * For women: Negative pregnancy test or menopausal for at least one year * For Group 1 only : PEA criteria and no alcohol consumption within the three days preceding the experiment. * For Group 2 only : PEA criteria, diagnosed with severe alcohol addiction and currently abstinent (for at least 15 days). * For Group 3 only : Non-alcohol-dependent controls. No alcohol consumption within the three days preceding the experiment and father diagnosed with severe alcohol addiction. * For Group 4 only : Non-alcohol-dependent controls. No alcohol consumption within the three days preceding the experiment.
Exclusion criteria
* Refusal of participation after clear and fair information on the study. * Visual or auditory sensory disability to participate in the study. * Benzodiazepines and / or Antipsychotic concomitant treatment. * History of (or current) neurologic disease * History of (or current) psychiatric disorder (apart alcohol-dependence for the PEA-alcohol-dependent group) * Psychoactive Substance Use or Abuse other than tobacco and alcohol. * Pregnant or breast-feeding women. * Underage (\<18 yo) or adults under guardianship, judicial protection, or deprived of liberty.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of correct answers of an emotional facial expression (EFE) | one day | Performance of an emotional facial expression (EFE) decoding task in EPA subjects and compare it to non-alcohol dependent controls |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Psychopathological assessment by Mini International Neuropsychiatric Interview MINI | one day | Presence of psychiatric disorders by a standardized psychiatric interview |
| Percentage of correct answers ant latency of behavioral answers | one day | Performance of behavioral tasks |
| State-Trait-Anxiety Inventory (STAI) score | one day | Score at STAI STAI is a psychological inventory based on a 4-point Likert scale and consists of 40 questions on a self-report basis |
| Beck Depression Inventory score | one day | Score at Beck Depression Inventory The BDI consisted of twenty-one questions about how the subject has been feeling in the last week. Each question had a set of at least four possible responses, ranging in intensity. (0) I do not feel sad/ (1) I feel sad./ (2) I am sad all the time and I can't snap out of it/ (3) I am so sad or unhappy that I can't stand it. When the test is scored, a value of 0 to 3 is assigned for each answer and then the total score is compared to a key to determine the depression's severity. The standard cut-off scores were as follows:0-9: indicates minimal depression/ 10-18: indicates mild depression/ 19-29: indicates moderate depression/ 30-63: indicates severe depression. |
| Toronto Alexithymia Scale TAS-20 score | one day | Score at TAS-20 The Toronto Alexithymia Scale is a measure of deficiency in understanding, processing, or describing emotions. The current version has twenty statements rated on a five-point Likert scale. ( range : Strongly disagree/Disagree/ Neither agree nor disagree/ Agree/ Strongly agree) |
Countries
France
Contacts
PRINCIPAL_INVESTIGATOROlivier COTTENCIN, MD, PhD
University Hospital, Lille
Outcome results
None listed