Cognitive Function
Conditions
Keywords
supplementation, cognition, cognitive function, vascular function, microvasculature
Brief summary
There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance . Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance.
Detailed description
There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance. Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance. The product in this study is aronia melanocarpa which contains polyphenols. A limited number of clinical studies have already been carried out to see the effect of similar products on cognitive functioning. However, these studies have often been done in older study populations or over a longer period of time. In this study, in healthy adolescents (ages between the 18-35 and with a BMI between 18.5 and 30), the investigators want to test the short term (7 days) effect of aronia melanocarpa extract on cognitive functioning. The investigators will also test the effect of supplementation on the particpant's mood, vascular function, blood biomarkers, retinal vasculature, and subjective cognition.
Interventions
DIETARY_SUPPLEMENTAronia
daily supplementation
DIETARY_SUPPLEMENTPlacebo
daily supplementation
Sponsors
BioActor B.V.
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
block randomization
Intervention model description
Cross-over study with 2 intervention conditions
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy young adults: ages between 18 and 35 * BM between 18.5-30 kg/m2
Exclusion criteria
* Current use of (antioxidant) dietary supplements and not willing to quit for the duration of the study duration * Pre-existing or history of neurological illness * High blood pressure (\>140 systolic and/or \>90 diastolic mmHg) * Use of medication that might have influence on endpoints (e.g. antidepressant) * Known pregnancy or lactation * Food allergy to the study product * Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study, to be decided by the principle investigator, in the 180 days prior to the study * Abuse of products (\> 20 alcoholic consumptions per week and drug usage) * Participation in a scientific intervention study which may interfere with this study in the 180 days prior to this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function | After 7 days of supplementation | CANTAB |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mood | After 7 days of supplementation | VAMS |
| Biomarkers in blood and saliva | After 7 days of supplementation | BDNF & cortisol |
| Vascular function | After 7 days of supplementation | SBP & DBP, PWA & PWV |
| Microvasculature | After 7 days of supplementation | Fundus photography |
| Subjective cognition | After 7 days of supplementation | Cognitive Failures Questionnaire |
Countries
Netherlands
Outcome results
None listed