Unexplained Infertility
Conditions
Brief summary
patients with previous failed ART cycles with high peripheral NK cells will be divided into 2 groups: one group of patients with previous failed ART cyles will undergo standard treatment but the other group will have in addition lipid emulsion &prednisolone & LMWH
Detailed description
patients with previous failed ART cycles with high peripheral NK cells will be divided into 2 groups: one group of patients with previous failed ART cyles will undergo standard treatment but the other group will have in addition lipid emulsion begin in the cycle before embryo transfer &prednisolone begin with the start of lipid emulsion & LMWH begin with the day of ET
Interventions
COMBINATION_PRODUCTcombination therapy for high peripheral NK cells
lipid emulsion & prednisolone & LMWH
Sponsors
Hawaa Fertility Center
Benha University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 37 Years
Healthy volunteers
No
Inclusion criteria
* patients with high peripheral NK cells \> 10% unexplained infertility cases cases with endometriosis
Exclusion criteria
* uterine factors poor responders\< 3 MII oocytes severe male factor & Azospermia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| chemical pregnancy rate | 14 days | quantitative serum test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy rate | 6 weeks of pregnancy | gestational sac and fetal echo by ultrasound |
Countries
Egypt
Outcome results
None listed