Parkinson Disease, Wearing Off Effect
Conditions
Keywords
wearing off, wearing-off 9 questionnaire, prevalence, sensitivity, specificity
Brief summary
The study would be designed as a multi-center cross-sectional investigation on the prevalence of Wearing-off in Parkinson's patients in Shanghai as well as related influencing factors.
Detailed description
PD patients would be randomly recruited into this investigation from around thirty hospital covering the 16 districts of Shanghai. The wearing off would be defined by two methods: the doctors' judgement or the WOQ-9 questionnaire which was a patient-determining tool. The investigation also includes the medicine, the severity of PD symptoms, the demographic factors. The study would be designed with the purpose of clarifying the prevalence of the wearing-off and its related influencing factors.
Interventions
DIAGNOSTIC_TESTWearing-off 9 questionnaire
The participants would receive appropriate anti-PD medical treatments according to the patients' need during the investigation.The anti -PD treatment would not be changed in the population of the participants.
Sponsors
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
35 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* have been clinical diagnosed with Parkinson's disease * have received stable anti-Parkinson's treatment before being recruited to the study.
Exclusion criteria
* being suspicious of atypical Parkinson syndrome or secondary Parkinson syndromes * have not received anti Parkinsonian treatment. * being combined with serious cognitive dysfunction or psychiatric symptoms * unable to complete the investigations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the prevalence of wearing off effect in Parkinson's patients that received stable anti Parkinsonian therapy in Shanghai of China | 1 year | every participant receives a clinical assessment of the wearing-off symptoms by a physician and completes a self rating scale of the wearing-off 9 questionnaire (WOQ-9) to obtain a prevalence of wearing-off positive individuals( wearing-off would be diagnosed by physicians during the clinical assessments) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the sensitivity and the specificity of the wearing-off 9 questionnaire in the diagnosis of wearing-off effect in Parkinson's disease. | 1 year | The physician assessment served as the standard for comparison with the WOQ-9 questionnaire. Sensitivity was defined as the probability that a PD patient, classified as having wearing-off (WO) according to physician assessment, would be classified as having the WO using the WOQ-9 questionnaire. The specificity was defined as the probability that a PD patient without the WO by physician assessments would be classified as being without the WO using the WOQ-9 questionnaire |
| the risk factors of wearing-off in Parkinson disease | 1 year | assess patients clinical characteristics and medical treatments, including the onset age, disease duration and daily levodopa dosage in the subsets of Parkinson patients with wearing-off diagnosed by physician assessment. |
Countries
China
Outcome results
None listed