Enteral Nutrition, Intestinal Mucosal Barrier, Sepsis, Th9 Cells
Conditions
Brief summary
The investigators aim to evaluate the roles of Th9/IL-9 in the mechanisms of early enteral nutrition (EEN) maintaining intestinal mucosal barrier in sepsis. The results of this study would lay the foundation for revealing the mechanisms of EEN improving immune imbalance of sepsis and provide a new idea to the early treatment of sepsis. In addition, the investigators also aim to evaluate the effects of different proportions of target total enteral nutrition on the prognosis of sepsis.
Interventions
OTHERNutrition
Enteral nutrition
Sponsors
Nanjing First Hospital, Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Clinical diagnosis of sepsis 2. Within 3 days of sepsis onset before ICU admission 3. No artificial nutrition (enteral or parenteral nutrition) were provided before ICU admission
Exclusion criteria
1. Ileus 2. Digestive tract hemorrhage 3. Inflammatory bowel disease 4. Abdominal hypertension (IAP \>25mmHg) 5. Cancer or chronic organ dysfunction (e.g., hepatic or renal dysfunction) 6. Malnutrition or immunodeficiency 7. Long-term use of hormones
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-d mortality | 28 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum Th9 lymphocyte percentages | 7 days | Serum Th9 lymphocyte percentages |
| Concentration of serum IL-9 | 7 days | Concentration of serum IL-9 |
| Concentration of serum iFABP | 7 days | Concentration of serum iFABP |
| Concentration of serum DAO | 7 days | Concentration of serum DAO |
Countries
China
Contacts
Primary ContactJie Zhou
Outcome results
None listed