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D Mannose for Prevention and Treatment of RUTIs

Oral D Mannose in the Prevention and Treatment of Recurrent Urinary Tract Infections: a Systematic Review

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03790254
Acronym
mannoseRUTIs
Enrollment
500
Registered
2018-12-31
Start date
2010-01-01
Completion date
2018-12-25
Last updated
2018-12-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antibiotic Prophylaxis, Antibiotic Resistance, Recurrent Urinary Tract Infections

Keywords

recurrent urinary tract infections, d mannose prophylaxis, antibiotic prophylaxis

Brief summary

The aim of this review is to address clinical reliability, efficacy and safety of long-term treatment with oral D Mannose for the prevention of recurrent urinary tract infections (RUTIs) in females.

Detailed description

A comprehensive systematic MEDLINE, Embase, Cochrane search was performed for English language reports published before December 2018 using the term recurrent urinary tract infections and d mannose. We searched Medline, Embase, and the Cochrane Register of Controlled Trials since January 2010 to December 2018. Eligible studies did not include non-oral therapy, local (vaginal) treatment in women with RUTIs. Study eligibility criteria- We identified eligible original articles. The heterogeneity of the available studies, their different rationale and aim, the assumption of d mannose for prophylaxis or treatment of recurrent UTIs need to be taken into account.

Interventions

Sponsors

Fondazione IRCCS Policlinico San Matteo di Pavia
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

recurrent urinary tract infections (RUTIs)

Exclusion criteria

Upper urinary tract infections, severe clinical symptoms, fever \> 37,5 with lumbar pain

Design outcomes

Primary

MeasureTime frameDescription
research literature data on d mannose for prevention and treatment of recurrent urinary tract infections.January 2010-December 2018literature search of the Medline, Embase, and Cochrane Library databases

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026