Acute Kidney Injury, Epidemiology, Risk Factor
Conditions
Keywords
incidence, prognosis, acute kidney injury, risk factor, post-craniotomy
Brief summary
The aim of this study was to investigate the incidence, risk factors and prognosis of acute kidney injury (AKI) in critically ill patients after craniotomy.
Detailed description
This was a prospective, single-center, cohort study that included adult patients who were admitted to the ICU of Beijing Tiantan Hospital from January 2017 to December 2018 after craniotomy and had a stay in the ICU for ≥ 24 hours (patients with preoperative AKI were excluded). Data collected included patient demographics (age, gender, underlying diseases, baseline serum creatinine, etc.), primary diagnosis, perioperative information, disease severity scores, as well as the occurrence of hypernatremia and hyperchloremia within 48 hours after ICU admission. For patients with AKI, pre-AKI sepsis and shock, and the recovery of renal function were recorded. All patients were followed until discharge, and information about prognosis was recorded. Multivariate regression analysis was used to identify the risk factors of AKI.
Interventions
OTHERAs a observational study, there is no intervention.
As a observational study, there is no intervention.
Sponsors
Beijing Tiantan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients underwent craniotomy * admitted into ICU ward and the ICU length of stay ≥24h
Exclusion criteria
* Age\< 18 years; * Patients with pre-existing acute kidney injury (AKI) and chronic kidney disease undergoing long-term renal replacement therapy (RRT) .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence and outcome of AKI after Craniotomy | during hospitalization | All adult patients who underwent craniotomy and admitted into intensive care unit (ICU) between January 2017 and December 2018 were screened for acute kidney injury. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Risk factors for AKI after Craniotomy | during hospitalization | Logistic regression analysis was employed to assess the risk factors for AKI. Variables with a significance level of P\<0.2 in univariate analysis and clinical relevance were included as adjustment factors in the regression analysis model. The calibration of the model was evaluated using the Hosmer-Lemeshow goodness-of-fit test. |
Countries
China
Outcome results
None listed