Periodontal Diseases
Conditions
Keywords
periodontal diseases, hepcidin, elisa, interleukin 6, interleukin 10
Brief summary
Periodontal disease refers to inflammatory disease of the periodontium caused by the host and/or pathogenic microorganisms. Anti-inflammatory and pro-inflammatory cytokines play a role in the periodontal inflammation process. The aim of this study was to evaluate the levels of hepcidin, interleukin (IL)-6, and IL-10 levels in gingival crevicular fluid (GCF) and in serum samples obtained from individuals with periodontal inflammation.
Detailed description
The study included 90 individuals, who were divided into three groups: periodontally healthy (PH) (n=30); gingivitis (G) (n=30); and chronic periodontitis (CP) (n=30). GCF and serum samples were obtained from each individual, and samples were evaluated using ELISA. Statistical evaluation of the data was performed using the SPSS packet data program.
Interventions
OTHERBiomarker test
Diagnostic biomarker study
Sponsors
Bulent Ecevit University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
32 Years to 52 Years
Inclusion criteria
* Systematically healthy patients. Patients who did not receive any medication or periodontal treatment within the previous 6 months
Exclusion criteria
* Individuals who smoked and women who were pregnant and/or lactating were excluded from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hepcidin levels | 1 year | Change in inflammatory phases |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| IL-6 levels | 1 year | Change in inflammatory phases |
| IL-10 levels | 1 year | Change in inflammatory phases |
Countries
Turkey (Türkiye)
Outcome results
None listed