Fluid Overload
Conditions
Brief summary
Impact of intraoperative use of pneumatic peristaltic compression device on hemodynamics vis a vis on fluid requirement during general anaesthesia and surgery.
Detailed description
Induction of general anaesthesia is associated with cardiac depression and peripheral vasodilatation resulting in hypotension .This hypotension can be corrected by giving intravenous fluid, or the vasoconstrictor. While optimum fluid balances in the perioperative period is of vital importance in overnight fasting patients to correct the fluid deficit, any fluid overload is not only counterproductive to the heart function but is associated with fluid retention in body and edema in postoperative period. Peristaltic pneumatic compression device, a variant of intermittent sequential compression of legs, uses higher pressure and longer compression cycles to avoid venous stasis in immobilized patients. Sequential compression devices have sleeves with pockets of inflation, which works to squeeze on the appendage in a milking action .The most distal areas will inflate initially, and the subsequent pockets will follow in the same manner. The primary aim of the device is to squeeze blood from the underlying deep veins to proximal side. When the inflatable sleeves deflate, the veins will replenish with blood. The intermittent compressions of the sleeves will ensure the movement of venous blood . Peristaltic Pneumatic Compression of the legs significantly reduces fluid demand and enhances stability during minor ear, nose, and throat surgery. Peristaltic Pneumatic Compression has the potential to support fluid restriction regimens during surgery .
Interventions
DEVICEHUNTLEIGH FLOWTRON ACS900
Sponsors
All India Institute of Medical Sciences, Rishikesh
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Masking description
Draping of the legs was done in both the groups.the care observer nor investigator were blinded for the allocation.
Intervention model description
About 60 patients of age group 25 to 50 belonging to American Society of Anesthesiologists (ASA) grade 1 and 2 were allocated to either control or sequential pneumatic compression device group .Allocation was done by sealed envelop technique.In the operating room,in the control group,the device was placed on operating table and was placed next to the patients calves.in the intervention group,the device was placed over calves and inflated during induction of General Anaesthesia (GA) and maintenance.legs were draped in both the groups.Femoral vein velocities were assessed using ultrasound in preoperative period , intraoperatively 15 minutes after induction of anaesthesia and in post-operative period.
Eligibility
Sex/Gender
ALL
Age
25 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA(American Society of Anaesthesiologists) grade I or II, of both genders * Age group of 25 to 50 years * Patients undergoing surgeries under GA(General Anaesthesia) for 2-3 hours
Exclusion criteria
* Patients expected to get major blood loss * Burns patients. * Patients with significant cardiac diseases. * Patients with pulmonary diseases and impaired renal function. * Lower limb surgeries and abdominal surgeries
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart Rate at T0 | 15 minutes pre induction | heart rate monitoring at T0 |
| Heart Rate at T1 | post induction heart rate | heart rate monitoring at T1 |
| Heart Rate at T2 | 15 minutes after induction | heart rate monitoring at T2 |
| Heart Rate at T3 | 30 minutes after induction | heart rate monitoring at T3 |
| Heart Rate at T4 | 60 minutes after induction | heart rate monitoring at T4 |
| Heart Rate at T5 | 120 minutes after induction | heart rate monitoring at T5 |
| Heart Rate at T6 | post operative period after 30 min in post anaesthesia care unit | heart rate monitoring at T6 |
| Systolic Blood Pressure at T0 | 15 min before induction | systolic blood pressure measurement at T0 |
| Systolic Blood Pressure at T1 | post induction | systolic blood pressure measurement at T1 |
| Systolic Blood Pressure at T2 | 15 min after induction | systolic blood pressure measurement at T2 |
| Systolic Blood Pressure at T3 | 30 min after induction | systolic blood pressure measurement at T3 |
| Systolic Blood Pressure at T4 | 60 min after induction | systolic blood pressure measurement at T4 |
| Systolic Blood Pressure at T5 | 120 min after induction | systolic blood pressure measurement at T5 |
| Systolic Blood Pressure at T6 | post operative period 30 min in post asnaesthesia care unit | systolic blood pressure measurement at T6 |
| Diastolic Blood Presure at T0 | 15 minutes before induction | Diastolic blood pressure measurement at T0 |
| Diastolic Blood Pressure at T1 | immediately after induction | Diastolic blood pressure measurement at T1 |
| Diastolic Blood Pressure at T2 | 15 minutes after induction | Diastolic blood pressure measurement at T2 |
| Diastolic Blood Pressure at T3 | 30 minutes after induction | Diastolic blood pressure measurement at T3 |
| Diastolic Blood Pressure at T4 | 60 minutes after induction | Diastolic blood pressure measurement at T4 |
| Diastolic Blood Pressure at T5 | 120 minutes after induction | Diastolic blood pressure measurement at T5 |
| Diastolic Blood Pressure at T6 | post induction 30 min in post anaesthesia care unit | Diastolic blood pressure measurement at T6 |
| Mean Blood Pressure at T0 | 15 minutes pre induction | Mean blood pressure measurement at T0 |
| Mean Blood Pressure at T1 | immediately after induction | Mean blood pressure measurement at T1 |
| Mean Blood Pressure at T2 | 15 minutes after induction | Mean blood pressure measurement at T2 |
| Mean Blood Pressure at T3 | 30 minutes after induction | Mean blood pressure measurement at T3 |
| Mean Blood Pressure at T4 | 60 minutes after induction | Mean blood pressure measurement at T4 |
| Mean Blood Pressure at T5 | 120 minutes after induction | Mean blood pressure measurement at T5 |
| Mean Blood Pressure at T6 | post operative 30 min in post anaesthesia care unit | Mean blood pressure measurement at T6 |
| Femoral Vein Velocity at T0 | 15 minutes pre induction | Femoral vein velocity measuement at T0 |
| Femoral Vein Velocity at T2 | 15 minutes after induction | Femoral vein velocity measurement at T2 |
| Femoral Vein Velocity at T6 | after 30 minutes in post anaesthesia care unit | Femoral vein velocity measurement at T6 |
| Femoral Vein Velocity Variance | 15 minutes pre induction to 30 minutes in post anaesthesia care unit | the variance in femoral vein velocity was calculated by subtracting the femoral vein velocity pre induction from femoral vein velocity 15 min after induction divided by mean of the two values in percentage |
| Femoral Artery Velocity at T0 | 15 minutes pre induction | Femoral artery velocity measurement at T0 |
| Femoral Artery Velocity at T2 | 15 minutes after induction | Femoral artery velocity measurement at T2 |
| Femoral Artery Velocity at T6 | after 30 minutes in post anaesthesia care unit | Femoral artery velocity measurement at T6 |
| Inferior Venacava Diameter (Maximum) at T0 | 15 min pre induction | inferior venacava diameter (maximum) meaurement at T0 |
| Inferior Venacava Diameter (Maximum) at T2 | 15 min after induction | inferior venacava diameter (maximum) meaurement at T2 |
| Inferior Venacava Diameter (Maximum) at T6 | after 30 min in post anaesthesia care unit | inferior venacava diameter (maximum) meaurement at T6 |
| Inferior Venacava Diameter (Minimum) at T0 | 15 min pre induction | inferior venacava diameter (minimum) meaurement at T0 |
| Inferior Venacava Diameter (Minimum) at T2 | 15 min after induction | inferior venacava diameter (minimum) meaurement at T2 |
| Inferior Venacava Diameter (Minimum) at T6 | after 30 min in post anaesthesia care unit | inferior venacava diameter (minimum) meaurement at T6 |
| Inferior Venacava Diameter Collapsibility Index at T0 | 15 min pre induction | the collapsibility index was calculated by dividing the difference of maximum inferior vena cava diameter and minimum inferior vena cava diameter by mean of the two diameters multiplied by 100.This was done for pre induction spontaneously breathing patients |
| Inferior Venacava Diameter Distensibility Index at T2 | 15 min after induction | the inferior venacava distensibility index for post induction mechanically ventilated patients. It was calculated by dividing the difference of maximum inferior vena cava diameter and minimum inferior vena cava diameter by minimum inferior vena cava diameters multiplied by 100 . |
| Inferior Venacava Diameter Collapsibility Index at T6 | after 30 minutes in post anaesthesia care unit | the collapsibility index was calculated by dividing the difference of maximum inferior vena cava diameter and minimum inferior vena cava diameter by mean of the two diameters multiplied by 100.This was done for pre induction spontaneously breathing patients |
| FLUID REQUIREMENT (Cumulative) | operative period | fluid requirement (cumulative) during the operative period. |
| Blood Loss During Operation | During operating procedure | Total blood loss during operation |
Participant flow
Recruitment details
The study was conducted from January 2017 to July 2018 at ALL INDIA INSTITUTE OF MEDICAL SCIENCES,RISHIKESH,UTTARAKHAND ,INDIA.
Participants by arm
| Arm | Count |
|---|---|
| Group A No intervention was done ,served as a control group. | 30 |
| Group B Intervention:peristaltic pneumatic compression device was placed on the legs of the patient and was active. HUNTLEIGH FLOWTRON ACS900 calf length device was used.
HUNTLEIGH FLOWTRON ACS900 | 30 |
| Total | 60 |
Baseline characteristics
| Characteristic | Group A | Group B | Total |
|---|---|---|---|
| Age, Continuous | 36.4 years STANDARD_DEVIATION 9.4 | 34.1 years STANDARD_DEVIATION 7.6 | 35.2 years STANDARD_DEVIATION 8.5 |
| Body Mass Index (BMI) | 22.8 kg^m2 STANDARD_DEVIATION 3.74 | 24.5 kg^m2 STANDARD_DEVIATION 4.2 | 23.65 kg^m2 STANDARD_DEVIATION 3.97 |
| Height | 1.62 meters STANDARD_DEVIATION 0.1 | 1.59 meters STANDARD_DEVIATION 0.1 | 1.60 meters STANDARD_DEVIATION 0.1 |
| Race and Ethnicity Not Collected | — | — | 0 Participants |
| Sex: Female, Male Female | 19 Participants | 18 Participants | 37 Participants |
| Sex: Female, Male Male | 11 Participants | 12 Participants | 23 Participants |
| Weight | 60.77 kilograms STANDARD_DEVIATION 8.73 | 62.13 kilograms STANDARD_DEVIATION 9.1 | 61.45 kilograms STANDARD_DEVIATION 8.91 |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 30 | 0 / 30 |
| other Total, other adverse events | 0 / 30 | 0 / 30 |
| serious Total, serious adverse events | 0 / 30 | 0 / 30 |
Outcome results
Primary
Blood Loss During Operation
Total blood loss during operation
Time frame: During operating procedure
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Blood Loss During Operation | 99.67 milliliters | Standard Deviation 50.34 |
| Group B | Blood Loss During Operation | 116.67 milliliters | Standard Deviation 41.8 |
p-value: 0.16t-test, 2 sided
Primary
Diastolic Blood Pressure at T1
Diastolic blood pressure measurement at T1
Time frame: immediately after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Diastolic Blood Pressure at T1 | 66.30 millimeters of mercury | Standard Deviation 12.93 |
| Group B | Diastolic Blood Pressure at T1 | 69.33 millimeters of mercury | Standard Deviation 11.96 |
p-value: 0.35t-test, 2 sided
Primary
Diastolic Blood Pressure at T2
Diastolic blood pressure measurement at T2
Time frame: 15 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Diastolic Blood Pressure at T2 | 65.37 millimeters of mercury | Standard Deviation 11.66 |
| Group B | Diastolic Blood Pressure at T2 | 66.53 millimeters of mercury | Standard Deviation 12.29 |
p-value: 0.708t-test, 2 sided
Primary
Diastolic Blood Pressure at T3
Diastolic blood pressure measurement at T3
Time frame: 30 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Diastolic Blood Pressure at T3 | 69.46 millimeters of mercury | Standard Deviation 15.42 |
| Group B | Diastolic Blood Pressure at T3 | 68.13 millimeters of mercury | Standard Deviation 12.15 |
p-value: 0.711t-test, 2 sided
Primary
Diastolic Blood Pressure at T4
Diastolic blood pressure measurement at T4
Time frame: 60 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Diastolic Blood Pressure at T4 | 69.36 millimeters of mercury | Standard Deviation 16.75 |
| Group B | Diastolic Blood Pressure at T4 | 69.16 millimeters of mercury | Standard Deviation 10.56 |
p-value: 0.956t-test, 2 sided
Primary
Diastolic Blood Pressure at T5
Diastolic blood pressure measurement at T5
Time frame: 120 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Diastolic Blood Pressure at T5 | 66.63 millimeters of mercury | Standard Deviation 11.53 |
| Group B | Diastolic Blood Pressure at T5 | 70.80 millimeters of mercury | Standard Deviation 9.93 |
p-value: 0.139t-test, 2 sided
Primary
Diastolic Blood Pressure at T6
Diastolic blood pressure measurement at T6
Time frame: post induction 30 min in post anaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Diastolic Blood Pressure at T6 | 70.66 millimeters of mercury | Standard Deviation 9.8 |
| Group B | Diastolic Blood Pressure at T6 | 75.80 millimeters of mercury | Standard Deviation 8.58 |
p-value: 0.035t-test, 2 sided
Primary
Diastolic Blood Presure at T0
Diastolic blood pressure measurement at T0
Time frame: 15 minutes before induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Diastolic Blood Presure at T0 | 76.00 millimeters of mercury | Standard Deviation 11.66 |
| Group B | Diastolic Blood Presure at T0 | 72.23 millimeters of mercury | Standard Deviation 13.3 |
p-value: 0.704t-test, 2 sided
Primary
Femoral Artery Velocity at T0
Femoral artery velocity measurement at T0
Time frame: 15 minutes pre induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Femoral Artery Velocity at T0 | 69.15 centimeters per second | Standard Deviation 14.08 |
| Group B | Femoral Artery Velocity at T0 | 76.25 centimeters per second | Standard Deviation 13.39 |
p-value: 0.03t-test, 2 sided
Primary
Femoral Artery Velocity at T2
Femoral artery velocity measurement at T2
Time frame: 15 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Femoral Artery Velocity at T2 | 67.74 centimeters per second | Standard Deviation 11.96 |
| Group B | Femoral Artery Velocity at T2 | 73.91 centimeters per second | Standard Deviation 11.62 |
p-value: 0.048t-test, 2 sided
Primary
Femoral Artery Velocity at T6
Femoral artery velocity measurement at T6
Time frame: after 30 minutes in post anaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Femoral Artery Velocity at T6 | 69.82 centimeters per second | Standard Deviation 11.78 |
| Group B | Femoral Artery Velocity at T6 | 76.63 centimeters per second | Standard Deviation 14.07 |
p-value: 0.047t-test, 2 sided
Primary
Femoral Vein Velocity at T0
Femoral vein velocity measuement at T0
Time frame: 15 minutes pre induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Femoral Vein Velocity at T0 | 29.35 centimeters per second | Standard Deviation 4.2 |
| Group B | Femoral Vein Velocity at T0 | 31.31 centimeters per second | Standard Deviation 7.28 |
p-value: 0.207t-test, 2 sided
Primary
Femoral Vein Velocity at T2
Femoral vein velocity measurement at T2
Time frame: 15 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Femoral Vein Velocity at T2 | 27.79 centimeters per second | Standard Deviation 4.02 |
| Group B | Femoral Vein Velocity at T2 | 33.61 centimeters per second | Standard Deviation 7.61 |
p-value: 0.142t-test, 2 sided
Primary
Femoral Vein Velocity at T6
Femoral vein velocity measurement at T6
Time frame: after 30 minutes in post anaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Femoral Vein Velocity at T6 | 28.35 centimeters per second | Standard Deviation 5.64 |
| Group B | Femoral Vein Velocity at T6 | 31.92 centimeters per second | Standard Deviation 5.96 |
p-value: 0.021t-test, 2 sided
Primary
Femoral Vein Velocity Variance
the variance in femoral vein velocity was calculated by subtracting the femoral vein velocity pre induction from femoral vein velocity 15 min after induction divided by mean of the two values in percentage
Time frame: 15 minutes pre induction to 30 minutes in post anaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Femoral Vein Velocity Variance | -5.419 percentage of velocity | Standard Deviation 8.444 |
| Group B | Femoral Vein Velocity Variance | 7.188 percentage of velocity | Standard Deviation 5.385 |
p-value: 0.0001t-test, 2 sided
Primary
FLUID REQUIREMENT (Cumulative)
fluid requirement (cumulative) during the operative period.
Time frame: operative period
Population: the population is same as the assigned population.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | FLUID REQUIREMENT (Cumulative) | 1456.67 milliliters | Standard Deviation 307.87 |
| Group B | FLUID REQUIREMENT (Cumulative) | 1291.66 milliliters | Standard Deviation 320.04 |
p-value: 0.043t-test, 2 sided
Primary
Heart Rate at T0
heart rate monitoring at T0
Time frame: 15 minutes pre induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Heart Rate at T0 | 85.23 beats per minute | Standard Deviation 17.81 |
| Group B | Heart Rate at T0 | 88.833 beats per minute | Standard Deviation 18.28 |
p-value: 0.443t-test, 2 sided
Primary
Heart Rate at T1
heart rate monitoring at T1
Time frame: post induction heart rate
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Heart Rate at T1 | 79.60 beats per minute | Standard Deviation 16.44 |
| Group B | Heart Rate at T1 | 88.13 beats per minute | Standard Deviation 18.35 |
p-value: 0.063t-test, 2 sided
Primary
Heart Rate at T2
heart rate monitoring at T2
Time frame: 15 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Heart Rate at T2 | 79.97 beats per minute | Standard Deviation 13.26 |
| Group B | Heart Rate at T2 | 88.57 beats per minute | Standard Deviation 20.3 |
p-value: 0.057t-test, 2 sided
Primary
Heart Rate at T3
heart rate monitoring at T3
Time frame: 30 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Heart Rate at T3 | 76.70 beats per minute | Standard Deviation 12.26 |
| Group B | Heart Rate at T3 | 84.77 beats per minute | Standard Deviation 16.8 |
p-value: 0.038t-test, 2 sided
Primary
Heart Rate at T4
heart rate monitoring at T4
Time frame: 60 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Heart Rate at T4 | 77.40 beats per minute | Standard Deviation 10.93 |
| Group B | Heart Rate at T4 | 83.56 beats per minute | Standard Deviation 14.83 |
p-value: 0.072t-test, 2 sided
Primary
Heart Rate at T5
heart rate monitoring at T5
Time frame: 120 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Heart Rate at T5 | 77.53 beats per minute | Standard Deviation 12.71 |
| Group B | Heart Rate at T5 | 82.17 beats per minute | Standard Deviation 14.22 |
p-value: 0.189t-test, 2 sided
Primary
Heart Rate at T6
heart rate monitoring at T6
Time frame: post operative period after 30 min in post anaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Heart Rate at T6 | 85.06 beats per minute | Standard Deviation 12.58 |
| Group B | Heart Rate at T6 | 88.23 beats per minute | Standard Deviation 13.87 |
p-value: 0.358t-test, 2 sided
Primary
Inferior Venacava Diameter Collapsibility Index at T0
the collapsibility index was calculated by dividing the difference of maximum inferior vena cava diameter and minimum inferior vena cava diameter by mean of the two diameters multiplied by 100.This was done for pre induction spontaneously breathing patients
Time frame: 15 min pre induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Inferior Venacava Diameter Collapsibility Index at T0 | 9.06 percentage of diameter | Standard Deviation 4.17 |
| Group B | Inferior Venacava Diameter Collapsibility Index at T0 | 9.32 percentage of diameter | Standard Deviation 1.62 |
p-value: 0.746t-test, 2 sided
Primary
Inferior Venacava Diameter Collapsibility Index at T6
the collapsibility index was calculated by dividing the difference of maximum inferior vena cava diameter and minimum inferior vena cava diameter by mean of the two diameters multiplied by 100.This was done for pre induction spontaneously breathing patients
Time frame: after 30 minutes in post anaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Inferior Venacava Diameter Collapsibility Index at T6 | 7.04 percentage of diameter | Standard Deviation 3.46 |
| Group B | Inferior Venacava Diameter Collapsibility Index at T6 | 10.03 percentage of diameter | Standard Deviation 4.1 |
p-value: 0.003t-test, 2 sided
Primary
Inferior Venacava Diameter Distensibility Index at T2
the inferior venacava distensibility index for post induction mechanically ventilated patients. It was calculated by dividing the difference of maximum inferior vena cava diameter and minimum inferior vena cava diameter by minimum inferior vena cava diameters multiplied by 100 .
Time frame: 15 min after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Inferior Venacava Diameter Distensibility Index at T2 | 11.05 percentage of diameter | Standard Deviation 4.17 |
| Group B | Inferior Venacava Diameter Distensibility Index at T2 | 8.39 percentage of diameter | Standard Deviation 2.841 |
p-value: 0.006t-test, 2 sided
Primary
Inferior Venacava Diameter (Maximum) at T0
inferior venacava diameter (maximum) meaurement at T0
Time frame: 15 min pre induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Inferior Venacava Diameter (Maximum) at T0 | 1.16 centimeters | Standard Deviation 0.14 |
| Group B | Inferior Venacava Diameter (Maximum) at T0 | 1.26 centimeters | Standard Deviation 0.17 |
p-value: 0.019t-test, 2 sided
Primary
Inferior Venacava Diameter (Maximum) at T2
inferior venacava diameter (maximum) meaurement at T2
Time frame: 15 min after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Inferior Venacava Diameter (Maximum) at T2 | 1.27 centimeters | Standard Deviation 0.11 |
| Group B | Inferior Venacava Diameter (Maximum) at T2 | 1.27 centimeters | Standard Deviation 0.17 |
p-value: 0t-test, 2 sided
Primary
Inferior Venacava Diameter (Maximum) at T6
inferior venacava diameter (maximum) meaurement at T6
Time frame: after 30 min in post anaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Inferior Venacava Diameter (Maximum) at T6 | 1.19 centimeters | Standard Deviation 0.13 |
| Group B | Inferior Venacava Diameter (Maximum) at T6 | 1.31 centimeters | Standard Deviation 0.17 |
p-value: 0.004t-test, 2 sided
Primary
Inferior Venacava Diameter (Minimum) at T0
inferior venacava diameter (minimum) meaurement at T0
Time frame: 15 min pre induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Inferior Venacava Diameter (Minimum) at T0 | 1.06 centimeters | Standard Deviation 0.13 |
| Group B | Inferior Venacava Diameter (Minimum) at T0 | 1.15 centimeters | Standard Deviation 0.15 |
p-value: 0.02t-test, 2 sided
Primary
Inferior Venacava Diameter (Minimum) at T2
inferior venacava diameter (minimum) meaurement at T2
Time frame: 15 min after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Inferior Venacava Diameter (Minimum) at T2 | 1.02 centimeters | Standard Deviation 0.09 |
| Group B | Inferior Venacava Diameter (Minimum) at T2 | 1.15 centimeters | Standard Deviation 0.15 |
p-value: 0t-test, 2 sided
Primary
Inferior Venacava Diameter (Minimum) at T6
inferior venacava diameter (minimum) meaurement at T6
Time frame: after 30 min in post anaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Inferior Venacava Diameter (Minimum) at T6 | 1.11 centimeters | Standard Deviation 0.13 |
| Group B | Inferior Venacava Diameter (Minimum) at T6 | 1.18 centimeters | Standard Deviation 0.17 |
p-value: 0.053t-test, 2 sided
Primary
Mean Blood Pressure at T0
Mean blood pressure measurement at T0
Time frame: 15 minutes pre induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Mean Blood Pressure at T0 | 90.04 millimeters of mercury | Standard Deviation 11.03 |
| Group B | Mean Blood Pressure at T0 | 92.19 millimeters of mercury | Standard Deviation 13.43 |
p-value: 0.502t-test, 2 sided
Primary
Mean Blood Pressure at T1
Mean blood pressure measurement at T1
Time frame: immediately after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Mean Blood Pressure at T1 | 78.38 millimeters of mercury | Standard Deviation 13.29 |
| Group B | Mean Blood Pressure at T1 | 81.82 millimeters of mercury | Standard Deviation 11.89 |
p-value: 0.35t-test, 2 sided
Primary
Mean Blood Pressure at T2
Mean blood pressure measurement at T2
Time frame: 15 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Mean Blood Pressure at T2 | 77.38 millimeters of mercury | Standard Deviation 11.46 |
| Group B | Mean Blood Pressure at T2 | 79.99 millimeters of mercury | Standard Deviation 11.41 |
p-value: 0.38t-test, 2 sided
Primary
Mean Blood Pressure at T3
Mean blood pressure measurement at T3
Time frame: 30 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Mean Blood Pressure at T3 | 82.42 millimeters of mercury | Standard Deviation 14.36 |
| Group B | Mean Blood Pressure at T3 | 82.05 millimeters of mercury | Standard Deviation 11.57 |
p-value: 0.914t-test, 2 sided
Primary
Mean Blood Pressure at T4
Mean blood pressure measurement at T4
Time frame: 60 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Mean Blood Pressure at T4 | 83.55 millimeters of mercury | Standard Deviation 15.79 |
| Group B | Mean Blood Pressure at T4 | 83.19 millimeters of mercury | Standard Deviation 10.14 |
p-value: 0.915t-test, 2 sided
Primary
Mean Blood Pressure at T5
Mean blood pressure measurement at T5
Time frame: 120 minutes after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Mean Blood Pressure at T5 | 81.16 millimeters of mercury | Standard Deviation 10.64 |
| Group B | Mean Blood Pressure at T5 | 85.76 millimeters of mercury | Standard Deviation 9.78 |
p-value: 0.087t-test, 2 sided
Primary
Mean Blood Pressure at T6
Mean blood pressure measurement at T6
Time frame: post operative 30 min in post anaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Mean Blood Pressure at T6 | 86.71 millimeters of mercury | Standard Deviation 8.98 |
| Group B | Mean Blood Pressure at T6 | 92.54 millimeters of mercury | Standard Deviation 8.27 |
p-value: 0.011t-test, 2 sided
Primary
Systolic Blood Pressure at T0
systolic blood pressure measurement at T0
Time frame: 15 min before induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Systolic Blood Pressure at T0 | 119.06 millimeters of mercury | Standard Deviation 11.71 |
| Group B | Systolic Blood Pressure at T0 | 122.1 millimeters of mercury | Standard Deviation 16.01 |
p-value: 0.406t-test, 2 sided
Primary
Systolic Blood Pressure at T1
systolic blood pressure measurement at T1
Time frame: post induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Systolic Blood Pressure at T1 | 102.33 millimeters of mercury | Standard Deviation 15.31 |
| Group B | Systolic Blood Pressure at T1 | 106.80 millimeters of mercury | Standard Deviation 14.82 |
p-value: 0.256t-test, 2 sided
Primary
Systolic Blood Pressure at T2
systolic blood pressure measurement at T2
Time frame: 15 min after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Systolic Blood Pressure at T2 | 100.73 millimeters of mercury | Standard Deviation 12.12 |
| Group B | Systolic Blood Pressure at T2 | 106.93 millimeters of mercury | Standard Deviation 13.45 |
p-value: 0.066t-test, 2 sided
Primary
Systolic Blood Pressure at T3
systolic blood pressure measurement at T3
Time frame: 30 min after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Systolic Blood Pressure at T3 | 106.23 millimeters of mercury | Standard Deviation 15.08 |
| Group B | Systolic Blood Pressure at T3 | 109.90 millimeters of mercury | Standard Deviation 12.93 |
p-value: 0.316t-test, 2 sided
Primary
Systolic Blood Pressure at T4
systolic blood pressure measurement at T4
Time frame: 60 min after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Systolic Blood Pressure at T4 | 111.10 millimeters of mercury | Standard Deviation 15.59 |
| Group B | Systolic Blood Pressure at T4 | 111.23 millimeters of mercury | Standard Deviation 12.45 |
p-value: 0.971t-test, 2 sided
Primary
Systolic Blood Pressure at T5
systolic blood pressure measurement at T5
Time frame: 120 min after induction
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Systolic Blood Pressure at T5 | 108.86 millimeters of mercury | Standard Deviation 10.92 |
| Group B | Systolic Blood Pressure at T5 | 115.70 millimeters of mercury | Standard Deviation 12.79 |
p-value: 0.03t-test, 2 sided
Primary
Systolic Blood Pressure at T6
systolic blood pressure measurement at T6
Time frame: post operative period 30 min in post asnaesthesia care unit
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Group A | Systolic Blood Pressure at T6 | 118.80 millimeters of mercury | Standard Deviation 10.34 |
| Group B | Systolic Blood Pressure at T6 | 126.03 millimeters of mercury | Standard Deviation 10.49 |
p-value: 0.009t-test, 2 sided