The Association of Cardiac Ion Channel Related Gene Polymorphism and Prolonged QTc Interval After Endotracheal Intubation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03788564

Enrollment

315

Registered

2018-12-27

Start date

2017-09-24

Completion date

2020-05-03

Last updated

2020-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergence Delirium

Brief summary

The QTc interval is affected by heart rate, medications and changes in the autonomic nervous system. The endotracheal laryngoscopy, the necessary step during general anesthesia, prolongs QTc interval. Changes in the flow of ion currents could result from the genetic variation of myocardial ion channels by gene polymorphism. This study is to investigate the association of cardiac ion channel related gene polymorphism and prolonged QTc interval after endotracheal intubation in adult patients.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

1. 20-65 years old 2. scheduled for general anesthesia requiring direct laryngoscopy

Exclusion criteria

1. Patients taking antihypertensive medication (beta-blocker, CCB) 2. patients taking other medications known to affect QTc interval 3. Patients with abnormal ECG and prolonged QTc (\>500 msec) 4. Diabetes, liver disease, kidney disease, heart failure, congenital heart disease 5. Severe electrolyte imbalance 6. illiterate, foreigners who cannot understand the consent form

Design outcomes

Primary

Measure	Time frame	Description
QTc interval	Before anesthesia, Before laryngoscopy, Right after laryngoscopy, 5 minutes after laryngoscopy	QTc interval prolongs followed by laryngoscopy due to changes in the autonomic nervous system. The restoration of the prolonged QTc could also be affected by the balance of autonomic nervous system or changes in the related cardiac ion channels.

Countries

South Korea

Outcome results