Airway Morbidity, Cognitive and Attention Disorders and Disturbances, Oxidative Stress
Conditions
Keywords
exhaled nitric oxide, Sick building syndrome, indoor air
Brief summary
A randomized crossover trial will be conducted in 90 primary school children in 3 classrooms in Shanghai, China. The effects of fresh air ventilation/filtration system, fresh air ventilation system with no filtration and natual ventilation will be compared on the effects of reducing indoor PM2.5 and chilhood health. Biological samples of children are going to be collected to investigate the associations between indoor air pollution and biomarkes of certain health effects.
Detailed description
A randomized crossover trial among 90 primary students in 3 classrooms in Shanghai, China will be performed. Three arms are going to be 1) fresh air filtration system, 2) fresh air system with no filtration and 3) natural ventilation. Each arm is going to be in use for five continuous weekdays followed by one week of wash-out. After one-week of wash out, a cross over change between 3 arms is going to be taked. Then the 2nd week of intervention is performed followed by the 2nd wash-out week. The same cross-over change between 3 arms is going to be repeated again until each classroom will be applied by all three arms of ventilation. A total of 5 weeks is required for the project. Children's biological samples including saliva, urine and skin samples will be collected as well as exhaled NO. A questionnaire on children's perception on air quality will be assessed as well.
Interventions
DEVICEFresh air system with filtration
Using fresh air ventilation combined with PM2.5 filtration system to reduce the indoor PM2.5 concentration in primarty school classrooms
Sponsors
Fudan University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
10 Years to 13 Years
Healthy volunteers
Yes
Inclusion criteria
* All invited primary school children in Grade 5 in an artibrarily selected school
Exclusion criteria
* Current airway symptoms (cough, airway infection, asthma et al.) * Acute infectious diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exhaled nitric oxide | within 2 hours of the end of intervention in each week | Airway inflammation biomarker |
| Oxidative stress biomarkers | within 2 hours of the end of intervention in each week | The level of lysozyme, cortisone and SIgA will be assessed in saliva and other oxidative biomarkers in the urine samples in children. |
| Sick building symdrom | within 2 hours of the end of intervention in each week | Answering questionnaire on sick biulding symdrom |
Countries
China
Outcome results
None listed