Amblyopia
Conditions
Brief summary
Objectives. To develop a new treatment for amblyopia using a perceptual learning approach. Hypothesis to be tested. Our proposed experiments are designed to investigate whether practicing a grating detection task can improve vision in patients with amblyopia. Design and subjects. A total of 36 patients with amblyopia will be randomized allocated into two intervention groups: Group 1, perceptual learning therapy. Group 2, occlusion therapy. A control group comprising of 18 subjects with normal vision will be recruited for comparison. A battery of tests will be used to assess a range of visual functions before and after the treatment intervention. Study instruments. Grating acuity testing system Interventions. We have established a clinical protocol for acuity training. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to indicate the location of the stimulus. Participants will be required to undertake 20 one-hour sessions of training. Main outcome measures. Resolution acuity, visual acuity, contrast sensitivity function
Interventions
OTHERAcuity training
The intervention will be a vision therapy. On each trial, a properly oriented stimulus will be presented randomly at one of the four locations on a flat monitor screen. The visual task is to identify the location of the stimulus.
OTHEROcclusion therapy
Participants will be required to patch the good eye for 20 days, 1 hour per day.
Sponsors
The Hong Kong Polytechnic University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
7 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Visual acuity in the amblyopic eye: 20/25 or worse
Exclusion criteria
* Manifest eye disease & nystagmus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of grating acuity | 20 hours | Grating acuity tests the participants' ability to resolve fine details. This study measures the change of grating acuity after 20 hours of vision training. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of visual acuity | 20 hours | Visual acuity tests the participants' ability to resolve letters.This study measures the change of visual acuity after 20 hours of vision training. |
| Change of contrast sensitivity | 20 hours | Contrast sensitivity reflects the participants' sensitivity to identify low contrast visual stimuli. This study measures the change of contrast sensitivity after 20 hours of vision training. |
| Change of stereopsis | 20 hours | Visual acuity tests the 3-D perception. This study measures the change of stereopsis after 20 hours of vision training. |
Countries
Hong Kong
Outcome results
None listed