Dexmedetomidine, Lidocaine, Nausea and Vomiting, Postoperative
Conditions
Keywords
Lidocaine, Dexmedetomidine, Postoperative nausea and vomiting, laparoscopic hysterectomy
Brief summary
BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV). The investigators investigated whether IV lidocaine plus dexmedetomidine infusion could better reduce the incidence of PONV after laparoscopic hysterectomy. METHODS: One hundred and twenty women with elective laparoscopic hysterectomy were randomly divided into two groups: patients in the lidocaine combined with dexmedetomidine group (LD group, n=60) received lidocaine (1.5 mg/kg loading, 1.5 mg/kg/h infusion) and dexmedetomidine (0.5 μg/kg loading, 0.4 μg/kg/h infusion) respectively. Patients in the control group (CON group, n=60) received the equal volume of saline. Primary outcome was the incidence of the first 48 h nausea, vomiting and PONV after surgery. The secondary outcomes included perioperative propofol and remifentanil consumption, postoperative fentanyl requirement, Ramsay sedation score, and bradycardia during post-anaesthesia care unit (PACU) stay.
Interventions
DRUGlidocaine and dexmedetomidine IV
Patients received IV bolus infusion of lidocaine (2%) 1.5 mg/kg and dexmedetomidine 0.5 µg/kg diluted with normal saline to 20 ml in the LD group respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion at rate of lidocaine 1.5 mg/kg and dexmedetomidine 0.4 µg/kg made up to 20 mL every hour until 30 min before the end of operation, respectively.
DRUGsaline IV
Patients received 20 ml normal saline and 20 ml normal saline in the CON group respectively, over 10 minutes before induction of anesthesia, followed by a continuous IV infusion 20 ml normal saline and 20 ml normal saline every hour until 30 min before the end of surgery
Sponsors
Xu Siqi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* American Society of Anesthesiologists (ASA) physical statusⅠand Ⅱ * Aged 40-55 years * Scheduled for elective laparoscopic hysterectomy
Exclusion criteria
* History of allergy to local anesthetics * Severe respiratory disease * Renal or hepatic insufficiency * History of preoperative opioids medication and psychiatric * preoperative bradycardia * preoperative atrioventricular block * Subjects who experienced severe hypotension (mean arterial pressure \[MAP\] \<60 mmHg) or bradycardia (heart rate \[HR\] \<40 bpm), urticaria, or arrhythmia during lidocaine and dexmedetomidine infusion period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative nausea | 0-2 hours after surgery | Our primary outcome was the incidence of nausea during the 0-2 hours after surgery |
| postoperative vomiting | 0-2 hours after surgery | Our primary outcome was the incidence of vomiting during the 0-2 hours after surgery |
| postoperative nausea and vomiting (PONV) | 0-2 hours after surgery | Our primary outcome was the incidence of PONV during the 0-2 hours after surgery |
Countries
China
Outcome results
None listed