Hyponatremia Due to Poly Ethylene Glycol (PEG)

Frequency of Hyponatremia Caused by Polyethylene Glycol Solution When Used as a Bowel Cleansing Agent for Colonoscopy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03787888

Enrollment

151

Registered

2018-12-26

Start date

2019-03-01

Completion date

2019-09-30

Last updated

2021-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyponatremia

Brief summary

Colonoscopy is a useful tool used in modern medicine and it is increasingly being employed for both diagnostic and therapeutic purposes. (Polyethelene glycol)PEG is very often used for bowel preparation.There are some cases of hyponatremia reported due to the use of PEG. This study was designed to find frequency of sodium disorders after bowel cleansing by Polyethylene glycol solution for colonoscopies in Dr. Ruth K.M. Pfau, Civil Hospital Karachi.

Detailed description

Colonoscopy is a useful tool used in modern medicine and it is increasingly being employed for both diagnostic and therapeutic purposes. PEG is very often used for bowel preparation. PEG solutions clean the bowel with less water and electrolyte shifts, primarily by causing mechanical effect of large-volume lavage 1. However, there are some cases of hyponatremia reported due to the use of PEG. Life-threatening fluid and electrolyte disturbances are more likely to occur in patients with risk factors, such as old age, use of SSRIs and thiazide diuretics, chronic kidney disease, congestive heart failure or with a history of electrolyte abnormalities 2. Although sporadic case reports of hyponatremia and other electrolyte imbalances after bowel preparation have been reported, but well-designed studies are lacking on this subject. Literature search did not reveal any local studies on this subject. This study was designed to find frequency of sodium disorders after bowel cleansing by Polyethylene glycol solution for colonoscopies in Dr. Ruth K.M. Pfau, Civil Hospital Karachi.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Inclusion criteria

1. Patients of either gender of age between 18-80 years undergoing colonoscopy. 2. Patients should have normal electrolytes before taking solution. 3. Patients should have given informed consent. 4. Patients should have taken solution adequately before procedure.

Exclusion criteria

1. Patients with chronic kidney disease 2. Patients on diuretics 3. Patients who are hyponatremic on first sample, i.e., before taking bowel cleansing agent. 4. Hypothyroidism \-

Design outcomes

Primary

Measure	Time frame	Description
Frequency of hyponatremia caused by polyethelene glycol.	12 hours	Frequency of hyponatremia caused by polyethelene glycol when used as a bowel cleansing agent for colonoscopy.

Countries

Pakistan

Outcome results