Coronary Artery Bypass Grafting, Ischemic Heart Disease
Conditions
Keywords
Ischemic Heart Disease, coronary artery bypass grafting, on-pump CABG, off-pump CABG, pump - assisted CABG, myeloperoxidase after CABG
Brief summary
Evaluation of outcomes of coronary artery bypass grafting.
Detailed description
Evaluation of outcomes of coronary artery bypass grafting (CABG) on-, off- pump, pump assisted as well as bimammary coronary artery bypass grafting. Objective: To assess myocardial ischemic-reperfusion damage during different kinds of CABG. To assess complications after during different kinds of CABG.
Interventions
PROCEDUREPump-assisted CABG.
Pump-assisted CABG.
PROCEDUREOn-pump CABG.
On-pump coronary artery bypass grafting.
PROCEDUREOff-pump CABG.
Off-pump coronary artery bypass grafting.
Sponsors
St. Petersburg State Pavlov Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Ischemic heart disease with indications for coronary artery bypass grafting.
Exclusion criteria
* valve disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Death. | 30 days during in stay. | Death during in-stay. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Death over 3 year after CABG. | within 3 years. | Death over 3 year after CABG. |
| Death over 5 year after CABG. | within 5 years. | Death over 5 year after CABG. |
| Acute myocardial infarction after CABG. | within 30 days after CABG | Acute myocardial infarction (Criteria: troponin I\>10+ST-elevation ECG+hemodynamic instability - record in medical history ot Cardiac Index\<2.3). |
| Shunt dysfunction during 30 days after CABG. | within 30 days after CABG | Criteria: Stenosis or occlusion of graft on coronary angiography. |
| Shunt dysfunction during 1 year after CABG. | within 1 year after CABG | Criteria: Stenosis or occlusion of graft on coronary angiography. |
| Shunt dysfunction during 3 years after CABG. | within 3 years after CABG | Criteria: Stenosis or occlusion of graft on coronary angiography. |
| Death over 1 year after CABG. | 1 year. | Death over 1 year after CABG. |
| Stroke. | within 30 days after CABG | Stroke after CABG (Record of neurologist in medical history or/and MRI findings). |
| Renal Dysfunction. | within 30 days after CABG | Increase serum creatinine level greater than 25% of reference value after CABG. |
| Atrial fibrillation. | within 30 days after CABG | New onset of atrial fibrillation after CABG (ECG findings: f-waves). |
| IABP | within 30 days after CABG | Intra-Aortic Balloon Pump (non - planned intervention aftet CABG due to hemodinamic instability (Cardiac Index \<2.3)) |
| Infection or febrile. | within 30 days after CABG | Infection or febrile (leucocytosis \> 9.0 more than 7 days after CABG or CRP \> 10 or t\>37.0 more than 7 days after CABG). |
| Residual myocardial ischemia. | within 30 days after CABG | New onset of myocardial contractility deterioration on echocardiography (with or without strain, documented hypokinetic or akinetic wall motion). |
| Shunt dysfunction during 5 years after CABG. | within 5 years after CABG | Criteria: Stenosis or occlusion of graft on coronary angiography. |
Countries
Russia
Contacts
Primary ContactAlexander Nemkov, PhD
Backup ContactVladimir Komok, PhD
Outcome results
None listed