Changes in Retinal Nerve Fiber Layer Thickness Detected by OCT in Diabetic Retinopathy After Panretinal Photocoagulation

Changes in Retinal Nerve Fiber Layer Thickness Detected by Optical Coherence Tomography in Diabetic Retinopathy After Panretinal Photocoagulation

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03786146

Enrollment

Registered

2018-12-24

Start date

2019-01-01

Completion date

2019-12-31

Last updated

2018-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinal Disease

Brief summary

Panretinal photocoagulation reduces the risk of visual loss by 50% in patients with diabetic retinopathy. It is recognized that laser expansion into the retina may be associated with photoreceptor loss, retinal pigment epithelial hypertrophy and visual field loss. Panretinal photocoagulation can cause alteration in retinal vascular permeability therefore, retinal thickness may be increased including retinal nerve fiber layer. On the contrary, it can damage retinal cells including ganglion cells, which may decrease the retinal nerve fiber layer thickness in the latter follow up period. Peripapillary retinal nerve fiber layer can be measured by optical coherence tomography which is a non-invasive technique for obtaining high resolution cross sectional images of a tissue.

Detailed description

Pre laser assessment: * Assessment of medical and family history * Refraction and best corrected visual acuity * Anterior segment examination using binocular slit lamp bi-microscopy. * Posterior segment examination. * OCT scan of peripapillary area Post laser assessment ( at 1,3 and 6 months): * Refraction and best corrected visual acuity. * Anterior segment examination using binocular slit lamp bi-microscopy. * Posterior segment examination. * OCT scan of peripapillary area.

Interventions

None listed

Study design

Observational model

CASE_CROSSOVER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 70 Years

Inclusion criteria

* Patients with a clinical diagnosis of proliferative diabetic retinopathy. * Treated by panretinal photocoagulation. * Age between 40-70 years old.

Exclusion criteria

* Patients with densely opaque media (as dense cataract or vitreous hemorrhage). * Glaucomatous patients. * Any other associated retinopathy.

Design outcomes

Primary

Measure	Time frame	Description
Retinal nerve fiber layer thickness measured by Optical Coherence Tomography (OCT) and expressed in micrometers.	0 (before laser treatment ).	A 3.4 mm OCT circular scan will be positioned around the optic nerve head.

Contacts

Primary Contactehab wasfi, assist prof

ehabinegypt@hotmail.com00201000373344

Outcome results