Prematurity, Subcutaneous Adipose Tissue
Conditions
Keywords
preterm, fatty acid, docosahexaenoic acid, arachidonic acid, infant, adipose tissue, subcutaneous adipose tissue
Brief summary
The fatty acid composition in blood and subcutaneous adipose tissue of infants that have an clinical indicated operation is studied.
Detailed description
Collection of: * subcutaneous adipose tissue of term infants and preterms after birth and at term during a clinically indicated operation. * blood before the operation. Measurement of the fatty acid composition (especially arachidonic acid and docosahexaenoic acid) in subcutaneous adipose tissue and blood. Aim is to compare the composition of the fatty acids in blood and adipose tissue of preterms at term and term infants. To calculate the fatty acid value in each infant the proportion of adipose tissue is determined with PEAPOD before discharge from hospital.
Interventions
OTHERadipose tissue
taking a sample of the adipose tissue during operation
OTHERblood
taking a blood sample when a peripheral venous catheter is inserted before operation
DIAGNOSTIC_TESTPEAPOD
Measurement of the total adipose tissue of the infant with PEAPOD (Air Displacement-Plethysmography, Infant Body Composition System, Cosmed, Rome, Italy)
Sponsors
University Hospital Tuebingen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Months
Healthy volunteers
No
Inclusion criteria
* meeting criteria of the 3 cohorts
Exclusion criteria
* metabolic diseases of the infant * genetic diseases * missing agreement for the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fatty acid composition of the subcutaneous adipose tissue and plasma | at the time of the operation | Fatty acid composition of the subcutaneous adipose tissue and plasma of preterms at term compared to the composition of infants after birth (within 14 days). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fatty acid composition of the subcutaneous adipose tissue and plasma of preterms with abdominal problems | time of the first operation until discharge home (at a postnatal age of up to 4-5 months at the most in very preterm infants) | Change of fatty acid composition of the subcutaneous tissue and plasma from first to second operation in preterms with abdominal operations, enterostomy |
| Fatty acid composition of the subcutaneous adipose tissue and plasma of preterms with abdominal problems and preterms without abdominal problems at term | time of the first operation until discharge home (at a postnatal age of up to 4-5 months at the most in very preterm infants) | Fatty acid composition of the subcutaneous adipose tissue and plasma of preterms at term compared to the composition of preterms at term with enterostomy. |
Countries
Germany
Contacts
Primary ContactKatrin Böckmann
Backup ContactAxel Franz, MD
Outcome results
None listed