Preemptive and Postoperative Intra-articualr Injection of Levobupivacaine and Tramadol

Comparative Study Between Preemptive and Postoperative Intra-articualr Injection of Levobupivacaine and Tramadol

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03785041

Enrollment

220

Registered

2018-12-24

Start date

2016-12-21

Completion date

2018-05-30

Last updated

2018-12-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain After Knee Arthroscop

Keywords

Tramadol, Intra-articular injection, Preemptive, post-arthroscopy pain, Levobupivacaine

Brief summary

Comparison between preemptive and postoperative intraarticular injection of tramadol on pain sensation after arthroscopy

Detailed description

220 patients assigned for therapeutic knee arthroscopy were divided into four equal groups in this prospective comparative study. All patients received IAI of 20 ml (0.5%) levopubivacaine alone in Group C; with 100 mg tramadol as PE (Group PE), at end of surgery (Group PO) or divided as 50 mg tramadol + 20 ml 0.25 % levobupivacaine as PE and 50 mg trmadol + 20 ml 0.25 % levobupivacaine as PO (Group PE/PO). Numeric rating scale (NRS) was used to assess pain sensation. Duration till request of rescue analgesia and number of requests were recorded. Patients' satisfaction concerning efficacy of PO analgesia was assessed using Iowa Satisfaction with Anesthesia Scale.

Interventions

DRUGLevobupivacaine Hydrochloride 2.5 MG/ML

Intrarticular injection of tramadol in addition to levobupivacaine in different doses preemptive and postoperative

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Patient physical status according to American Society of Anesthesiology (ASA) classes I-II * Patients free of general diseases prohibiting the use of local anesthesia.

Exclusion criteria

* Patients had allergy for local anesthetics or to tramadol * Patients have psychological or neurological disorders inducing difficulty for evaluation of pain scoring.

Design outcomes

Primary

Measure	Time frame	Description
Pain control	Pain assessment for 12 hours postoperative	Pain sensation after arthroscopy assessed by numeric rating scale depending upon patient facial appearance with severe patient expressing high score and no pain with lowest score

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026