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Changes of Pain Sensitivity During Rehabilitation of Patients Suffering From Whiplash Associated Disorders

Whiplash Associated Disorders - Sensory Changes During Rehabilitation

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03784196
Enrollment
44
Registered
2018-12-21
Start date
2016-05-16
Completion date
2019-10-22
Last updated
2020-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, Neck Pain, Whiplash, Whiplash Injury

Keywords

WAD, rehabilitation, whiplash, neck pain, pain sensitivity

Brief summary

This study investigates the sensory profile of people suffering from whiplash associated disorders (WAD) during rehabilitation.

Detailed description

Altered pain sensitivity is commonly reported in WAD populations when compared to a healthy control group but how/if this changes over time during rehabilitation is unclear. This study investigates the effect of 2 weeks rehabilitation protocol on pain sensitivity in a group suffering from WAD compared to a healthy control group.

Interventions

WAD participants underwent 2-weeks rehabilitation.

Sponsors

Aalborg University
CollaboratorOTHER
Universidad San Jorge
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

WAD * No more than 3 weeks since MVA/WAD * WAD grade II defined by Quebec Task Force classification Controls • Being healthy and free from any pain specific to the low back and/or in general

Exclusion criteria

Applies for both groups: * Pain related to a specific pathology such as spinal stenosis, metastasis, fracture, nerve lesions or injuries to the brain etc. * Previous painful condition (including neck pain) in the previous 6 months. * Prior surgery in the neck or shoulder area. * Radiculopathy. * Multiple painful sites/areas unrelated to the neck pain. * Operation to the spine. * Any neurological or systemic diseases which can affect the outcome measures. * Pregnancy. * Lack of ability to cooperate. Additional

Design outcomes

Primary

MeasureTime frameDescription
Changes in Pressure Pain ThresholdsBaseline, 2 weeks, 6 monthsChanges in pressure pain thresholds will be determined with pressure algometry bilaterally over the neck and leg. PPT is defined as the exact time point where the pressure is first being perceived at painful.
Changes in Conditioned Pain ModulationBaseline, 2 weeks, 6 monthsChanges in condition pain modulation (CPM) will be measures by recording PPT bilaterally over the neck and leg prior to and following a painful stimuli (a pressure cuff is inflated around the upper arm to create the conditioned stimulus). CPM value is calculated by subtracting raw PPT (without painful stimuli) from PPT under the conditioned stimulus.

Secondary

MeasureTime frameDescription
Neck Disability Index (NDI)Baseline, 2 weeks, 6 monthsA validated and reliable questionnaire that estimates the impact of neck pain on normal daily activities (self-rated disability). NDI consists of 10 dimensions that all are score from 0-5 giving a maximum score of 50. The overall score indicates the level of disability. Below 5 = no disability whereas increased scores indicates increased levels of disability.

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026