Study Of The Metabolic Parameters Of Uterine Muscle Cells

Study Of The Metabolic Parameters Of Uterine Muscle Cells In Cold Ischemia From Hysterectomies Programmed For Benign

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03784157

Enrollment

Registered

2018-12-21

Start date

2018-12-13

Completion date

2020-12-13

Last updated

2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemia

Keywords

Hysterotomy, UTERINE MUSCLE CELLS, ISCHEMIA, COLD ISCHEMIA

Brief summary

To date, no transplant has allowed pregnancy from a donor in a state of brain death. One of the main reservations lies in the ischemic properties of the uterine graft between the sampling time and the grafting time. Investigators propose to carry out a prospective monocentric study at the University Hospitals of Strasbourg in 2018/2019: the objective would be to study physiologically the time of ischemia of the uterine muscle The objective is to carry out a preparatory study on healthy uteri to study the ischemic properties of uterine muscle from living markers: study of mitochondrial respiration and free radical production on uterine muscle samples If the markers are reliable, they would then be used to measure the ischemia of whole uteri collected at the end of the multi-organ retrieval process from donors in a state of brain death and stored in tissue survival media.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Inclusion criteria

* \- Adult patient * Patient benefiting from the routine management of a programmed hysterectomy by vaginal, laparoscopic or laparotomy for benign pathologies (fibroma, adenomyosis, genital prolapse,...) within the CMCO * Patient consenting to the use of cells from her uterus for incineration for research purposes * Patient giving her consent for the use of her medical data for the purposes of this research. * Patient agreeing to participate in the study

Exclusion criteria

* \- Patient refusing to participate in the study * Patient under the protection of justice * Patient under guardianship or curatorship * Suspicion of gynaecological malignant pathology * Pregnant or breastfeeding woman * Impossibility to give the subject informed information (difficulties in understanding the subject...)

Design outcomes

Primary

Measure	Time frame	Description
Ischemia	1 hour after sampling	Study physiologically the time of ischemia of the uterine muscle 1 hour after sampling

Countries

France

Outcome results