A Validation Study of The Relationship Between ALDH2 and Aortic Dissection

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03780738

Acronym

VaRALAD

Enrollment

200

Registered

2018-12-19

Start date

2018-10-01

Completion date

2019-09-30

Last updated

2018-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Dissection

Keywords

Aortic dissection, Aldehyde dehydrogenase 2 polymorphism

Brief summary

The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Chinese Han people diagnosed with aortic dissection in Guangdong Provincial People's Hospital

Exclusion criteria

* Aortic dissection based on trauma, connective tissue diseases and pregnancy * Patients with tumor * Patients with no written consensus

Design outcomes

Primary

Measure	Time frame	Description
Number of patients with different ALDH2 genotype	1-30 days after samples collected	DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene.

Countries

China

Contacts

Primary ContactXiao Li

jfm3145496@163.com+8618560088301

Outcome results